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  • Artikel: DFG Deutsche Nationallizenzen  (7)
  • Chemistry  (2)
  • creatine kinase  (2)
  • 2,6-dichlorophenol  (1)
  • Induced photoreceptor noise  (1)
  • Psychotic Anxiety Reaction  (1)
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  • Artikel: DFG Deutsche Nationallizenzen  (7)
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Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    Voltage noise accompanying chemically-induced depolarization of insect photoreceptors (1980)
    Springer
    European biophysics journal 6 (1980), S. 235-251 
    Details
    ISSN: 1432-1017
    Schlagwort(e): Alcohols ; Induced photoreceptor noise ; Phototransduction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Physik
    Notizen: Abstract Intracellular potentials are recorded from photoreceptors in a superfused preparation of the retina of a locust compound eye. Chloral hydrate and alkyl alcohols induce a rapid, superfusing reversible depolarization of these photoreceptors when dissolved in the saline. Analysis of voltage noise accompanying depolarization by chloral hydrate suggests that depolarizing ionic pathways are opened briefly and randomly in time in the photoreceptor membranes. This conclusion is supported by measurements of the cell resistance and of voltage noise amplitude as a function of membrane potential. Replacement of superfusate sodium by choline reversibly reduces the effects of chloral hydrate, suggesting that the ionic pathways opened are permeable by sodium. The voltage noise induced by chloral hydrate is compared to that during depolarization by steady illumination of the same cell. As the illumination intensity is increased, the amplitude and the shape of the power spectrum of light-induced voltage noise approach those of drug-induced noise at the same depolarization level. The possibility that these phenomena represent alterations in the mechanism of phototransduction is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00538226
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  • 2
    Digitale Medien
    Digitale Medien
    Expression of the mitochondrial creatine kinase genes (1994)
    Springer
    Molecular and cellular biochemistry 133-134 (1994), S. 235-243 
    Details
    ISSN: 1573-4919
    Schlagwort(e): creatine kinase ; mitochondria ; metabolism ; creatine phosphate shuttle ; gene expression ; muscle
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Mitochondrial Creatine Kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine, and exists in mammals as two isoenzymes encoded by separate genes. In rats and humans, sarcomere-specific MtCK (sMtCK) is expressed only in skeletal and heart muscle, and has 87% nucleotide identity across the 1257 bp coding region. The ubiquitous isoenzyme of MtCK (uMtCK) is expressed in many tissues with highest levels in brain, gut, and kidney, and has 92% nucleotide identity between the 1254 bp coding regions of rat and human. Both genes are highly regulated developmentally in a tissue-specific manner. There is virtually no expression of sMtCK mRNA prior to birth. Unlike cytosolic muscle CK (MCK) and brain CK (BCK), there is no developmental isoenzyme switch between the MtCKs. Cell culture models representing the tissue-specific expression of either sMtCK or uMtCK are available, but there are no adequate developmental models to examine their regulation. Several animal models are available to examine the coordinate regulation of the CK gene family and include 1) Cardiac Stress by coarctation (sMtCK, BCK, and MCK), 2) Uterus and placenta during pregnancy (uMtCK and BCK), and 3) Diabetes and mitochondrial myopathy (sMtCK, BCK, and MCK). We report the details of these findings, and discuss the coordinate regulation of the genes necessary for high-energy transduction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01267957
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  • 3
    Digitale Medien
    Digitale Medien
    Molecular characterization of the creatine kinases: and some historical perspectives (1998)
    Springer
    Molecular and cellular biochemistry 184 (1998), S. 153-167 
    Details
    ISSN: 1573-4919
    Schlagwort(e): creatine kinase ; transcription factors ; myogenesis ; mitochondrion ; energy ; gene family
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006807515892
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  • 4
    Digitale Medien
    Digitale Medien
    The effects of drugs on objective measures of thought disorder in schizophrenic patients (1972)
    Springer
    Psychopharmacology 24 (1972), S. 147-158 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Process Schizophrenia ; Psychotic Anxiety Reaction ; Overinclusive Psychosis ; Phenothiazine Therapy ; Sernyl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Results of studies using tests of thought disorder suggest the possibility of distinguishing three separate and possibly independent syndromes among schizophrenic patients. “Process schizophrenics” seem to be characterized by a relatively low I.Q., general psychomotor retardation, a slow reaction time, perceptual underconstancy, concreteness and distractibility. Many of these specific defects can be produced in normal people by the drug “Sernyl”, but not by other drugs studied. No known drug (such as the phenothiazines) has been shown to improve all these dysfunctions significantly in schizophrenic patients. “Psychotic anxiety reaction” is a label which might be used to describe the thinking disturbances found in many reactive schizophrenics. It consists of a tendency to produce unusual responses in a wide range of experimental situations, accompanied by an unusual degree of “perceptual constancy”. These behavioral abnormalities might be due to the disruptive effects of a very high level of anxiety, and might be alleviated by depressant drugs. “Overinclusive Psychosis”, characterizes a minority of hyperactive schizophrenics and some manic patients, who seem to use unusually broad and vaguely defined concepts in their thinking. LSD may induce this type of thinking in normal subjects, and it is possible that it may respond to phenothiazine medication.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00402910
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  • 5
    Digitale Medien
    Digitale Medien
    Phenols as pheromones of ixodid ticks: A general phenomenon? (1975)
    Springer
    Journal of chemical ecology 1 (1975), S. 501-509 
    Details
    ISSN: 1573-1561
    Schlagwort(e): ticks ; ixodid ticks ; pheromone ; Rhipicephalus appendiculatus ; Rhipicephalus pulchellus ; phenol ; cresol ; 2,6-dichlorophenol ; salicylaldehyde
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Extracts of femaleRhipicephalus appendiculatus Neumann andR. pulchellus Neumann, vectors or potential vectors of East Coast fever, have yielded phenol andp-cresol. The same phenols have been found in five additional species of hard ticks, three of which also contained 2,6-dichlorophenol. Salicylaldehyde appeared as another phenolic component in four of these species. On the basis of this information- and of the rather limited literature available, it appears that ixodid ticks may generally utilize simple phenols as attractants. Behavioral observations suggest a role of the phenols in the meeting of the sexes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00988590
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  • 6
    Digitale Medien
    Digitale Medien
    Investigation into the interactions of metals and metal ions in polymer matrices (1986)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 144 (1986), S. 51-72 
    Details
    ISSN: 0003-3146
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Beschreibung / Inhaltsverzeichnis: Es wurde die Dispersion von Solen einiger übergangsmetalle (Gold, Eisen(III)-oxid · H2O, Chromhydroxid) in einem wasserlöslichen Polymeren (PVA 4-88) untersucht und von den daraus hergestellten Filmen ein Vergleich ihrer mechanischen und elektrischen Eigenschaften gemacht. In Erweiterung auf nichtwäßrige Lösungsmittel (Dimethylformamid, Tetrahydrofuran) wurden die Wechselwirkungen von mehrwertigen Metallionen (Fe(III), Al(III), Ti(IV), Zr(IV), Pd(O), Ag(O), Au-Sole) mit einem spezifischen metallkomplexierenden Polymeren (Polyacrylamidoxim) und einem Blockcopolymeren, das Styrol und Butadien (Buna BL 6533) enthält, untersucht.
    Notizen: The dispersion of transition metal sols (gold, ferric hydrous oxide, chromium hydroxide) in a water soluble polymer (PVA 4-88) was investigated and from the films produced, a comparison made of their mechanical and electrical properties. Extending to non aqueous solvents (dimethylformamide, tetrahydrofuran) interactions of polyvalent metal ions (Fe(III), Al(III), Ti(IV), Zr(IV), Pd(0), Ag(0), Au sols) with a specific metal complexing polymer (poly(acrylamideoxime)) and a block copolymer containing styrene and butadiene (Buna BL 6533) were investigated.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/apmc.1986.051440105
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  • 7
    Digitale Medien
    Digitale Medien
    Generation of crystal structures of acetic acid and its halogenated analogs (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 19 (1998), S. 1-20 
    Details
    ISSN: 0192-8651
    Schlagwort(e): crystal structure prediction ; polymorphism ; atom-atom potential method ; force fields ; crystal structure solution ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Informatik
    Notizen: The approach of Karfunkel and Gdanitz has been used to predict possible crystal structures of acetic acid and three of its monohalogenated analogs starting with the molecular structure alone. The results demonstrate that this approach is capable of finding many, if not all, of the possible packing arrangements of molecules of this size, but that it is not currently capable of correctly ranking these structures in terms of their enthalpy. This deficiency is probably due to inadequacies in the force field used to minimize the structures. The inadequacies relate to the description of acidic hydrogen bonds and halogen-halogen interactions.   © 1998 John Wiley & Sons, Inc.   J Comput Chem 19: 1-20, 1998
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
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