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  • Articles: DFG German National Licenses  (3)
  • kidney  (2)
  • 21.10.-k  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 26 (1988), S. 705-716 
    ISSN: 1573-4927
    Keywords: Mus caroli ; Mus musculus ; androgen ; kidney ; submandibular gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Androgen controls the expression of β-glucuronidase and several other proteins in the kidney of the standard laboratory mouse,Mus musculus. Other species within the genusMus exhibit a variety of response patterns for kidney β-glucuronidase and other markers of androgen action. We have investigated the mechanism of androgen action inM. caroli, aMus species that does not produce β-glucuronidase in response to testosterone. The failure of testosterone to induce β-glucuronidase inM. caroli females cannot be overcome by treatment with dihydrotestosterone, with pharmacological doses of testosterone propionate or dihydrotestosterone propionate, or with a variety of potent androgen analogues. All of these compounds induce kidney β-glucuronidase inM. musculus females and kidney ornithine decarboxylase, submandibular gland renin, and submandibular gland epidermal growth factor in bothM. caroli andM. musculus females. Furthermore, kidney androgen receptor proteins fromM. caroli andM. musculus animals have the same sedimentation characteristics on sucrose density gradients. These data indicate that androgen resistance inM. caroli is not due to deficient 5α-reductase or aberrant hormone metabolism producing suboptimal levels of functional androgen and is not caused by a defective androgen receptor. They suggest that the resistance of β-glucuronidase inM. caroli kidney to induction by androgen occurs at the level of the β-glucuronidase gene.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 26 (1988), S. 705-716 
    ISSN: 1573-4927
    Keywords: Mus caroli ; Mus musculus ; androgen ; kidney ; submandibular gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Androgen controls the expression of β-glucuronidase and several other proteins in the kidney of the standard laboratory mouse,Mus musculus. Other species within the genusMus exhibit a variety of response patterns for kidney β-glucuronidase and other markers of androgen action. We have investigated the mechanism of androgen action inM. caroli, aMus species that does not produce β-glucuronidase in response to testosterone. The failure of testosterone to induce β-glucuronidase inM. caroli females cannot be overcome by treatment with dihydrotestosterone, with pharmacological doses of testosterone propionate or dihydrotestosterone propionate, or with a variety of potent androgen analogues. All of these compounds induce kidney β-glucuronidase inM. musculus females and kidney ornithine decarboxylase, submandibular gland renin, and submandibular gland epidermal growth factor in bothM. caroli andM. musculus females. Furthermore, kidney androgen receptor proteins fromM. caroli andM. musculus animals have the same sedimentation characteristics on sucrose density gradients. These data indicate that androgen resistance inM. caroli is not due to deficient 5α-reductase or aberrant hormone metabolism producing suboptimal levels of functional androgen and is not caused by a defective androgen receptor. They suggest that the resistance of β-glucuronidase inM. caroli kidney to induction by androgen occurs at the level of the β-glucuronidase gene.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 333 (1989), S. 237-246 
    ISSN: 1434-601X
    Keywords: 21.10.-k ; 23.20.-g ; 23.40.-s
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The beta-gamma spectroscopic study of22O is presented. This nucleus, produced as a projectile-like fragment from the interaction of a 60 MeV/n40Ar beam with a Be target, has been separated by the LISE spectrometer. Several gamma rays from22O decay have been observed, from which a half-life of (2.25±0.15)s has been determined. Accurate excitation energies have been deduced for several states in22F. A partial beta decay scheme of22O has been established. Experimental results have been compared with shell model calculations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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