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  • Artikel: DFG Deutsche Nationallizenzen  (5)
  • Rat  (2)
  • 21.10.Gv  (1)
  • 29.30.Kv  (1)
  • 34.10.+x  (1)
  • Basidiomycete  (1)
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  • Artikel: DFG Deutsche Nationallizenzen  (5)
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Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    Investigations on behavioral effects of an extract of Cannabis sativa L. in the rat (1981)
    Springer
    Psychopharmacology 75 (1981), S. 144-147 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Cannabis ; catecholamines ; Hyperreactivity ; Hyperthermia ; Pimozide ; Atropine ; 6-OHDA ; Stereotypy ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The behavioral responses of the rat to an extract of Cannabis sativa were examined after IP injection of 5, 15 and 30 mg/kg (expressed as Δ 9 tetrahydrocannabinol). The lowest dose of the extract induced stereotyped behavior (rhythmic head movements, intermittent gnawing and sniffing) together with hypersensitivity to stimuli and hyperthermia. The administration of higher doses of the extract resulted, initially, in similar behavioral effects but of greater intensity, followed by a cataleptic state alternating with atonic muscular prostration; rectal temperature was decreased. Pre-treatment with 6-hydroxydopamine (6-OHDA, which produces degeneration of catecholamine-containing nerve terminals) or pimozide (blocker of dopamine receptors) significantly reduced both stereotypy and hyperreactivity. Thermic effects were also antagonized by 6-OHDA pre-treatment. Cannabis-induced catalepsy was enhanced by pimozide but reduced by atropine (3 mg/kg SC). These results support the hypothesis that catecholamines play an important role in the complex behavioral effects of cannabis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432176
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  • 2
    Digitale Medien
    Digitale Medien
    Evaluation of local cerebral glucose utilization and the permeability of the blood-brain barrier in the genetically epilepsy-prone rat (1992)
    Springer
    Experimental brain research 88 (1992), S. 151-157 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Genetically epilepsy-prone rat ; Blood-brain barrier ; Local cerebral glucose utilization ; Thyroid hormones ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The genetically epileptic-prone rat (GEPR) is a valuable model for the study of gene-linked abnormalities involved in epilepsy. In comparison with normal Sprague-Dawley controls, we found, in GEPRs, a marked depression in local cerebral glucose utilization, widespread throughout the brain. This depression was accompanied by a significant increase of blood-brain barrier permeability and a reduction in regional blood volume. Finally GEPRs showed lower plasma levels of total triiodothyronine than normal controls. One can speculate that alterations in cerebral metabolism and microvascular regulation and thyroid hormone imbalance may be gene-linked factors involved in seizure susceptibility.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02259136
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  • 3
    Digitale Medien
    Digitale Medien
    Meiotic segregation and recombination of the intergenic spacer of the ribosomal DNA in the ectomycorrhizal basidiomycete Laccaria bicolor (1996)
    Springer
    Current genetics 30 (1996), S. 332-337 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Key words Laccaria bicolor ; Basidiomycete ; Intergenic spacers ; Ribosomal DNA ; Meiotic recombination ; Heteroduplex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  The aim of this study was to clarify the inheritance of the nuclear ribosomal DNA (rDNA) in the ectomycorrhizal basidiomycete Laccaria bicolor S238N in order to resolve inter- and within-strain relationships in forest ecosystems. PCR amplification of the intergenic spacer (IGS) was carried out in the dikaryotic mycelium and its haploid progeny. In the dikaryotic mycelium, multiple amplification products were produced for the 25s/5s (IGS1) and 5s/17s (IGS2) intergenic spacers. The 4.5- and 4.0-kb fragments of IGS2 (haplotypes α and β, respectively) were observed to occur in a 1:1 ratio within the haploid progeny as a result of divergent IGS haplotypes in the two separate nuclei. Recombinant monokaryons having both types of IGS2 occurred at a low frequency (6.5%; 60 kb per centimorgan) during meiosis. Haplotypes α and β of IGS1 cross-hybridized forming heteroduplexes during the PCR temperature cycle. The two IGS1 haplotypes differed only by the repeat number of a TA2C3 motif and co-segregated with the IGS2 haplotypes. Heteroduplex formation and IGS polymorphism provide information that is helpful in distinguishing between introduced exotic L. bicolor S238N and indigenous populations of Laccaria spp. in forest ecosystems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002940050141
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  • 4
    Digitale Medien
    Digitale Medien
    Total cross sections of reactions induced by neutron-rich light nuclei (1989)
    Springer
    The European physical journal 332 (1989), S. 457-465 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 21.10.-k ; 07.75.+h ; 21.10.Gv ; 25.70.Np ; 27.20.+n
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Total nuclear reaction cross-sections are determined by means of a 4π-γ method. The results cover a wide span of targets for various stable beams. The validity of the method is shown in a combined systematics including also the results of transmission-type experiments. The data are very well described by the formula developed by Kox et al. The same method is applied to secondary fragment beams produced from a 44 MeV/u22Ne beam on a 332mg/cm2 181Ta target. Using the LISE spectrometer the fragments4, 6He,6–9, 11Li,7, 9–12, 14Be,10–15, 17B11–19C,13–19N,15–21O,18– 21F and20,21 Ne are analyzed and transported to interact with a 199.4 mg/cm2 Cu target surrounded by a 4π-γ counter. The measured total reaction cross-sectionsσ R are discussed in terms of the reduced strong absorption radiusr 0 and compared with other experimental results.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01292431
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  • 5
    Digitale Medien
    Digitale Medien
    K-shell ionization induced by 30 MeV/u argon and neon beams (1986)
    Springer
    The European physical journal 2 (1986), S. 223-231 
    Details
    ISSN: 1434-6079
    Schlagwort(e): 29.30.Kv ; 32.70.Jz ; 34.10.+x ; 34.50.Fa
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We have studiedK-shell ionization induced by 30 MeV/u Ne and Ar projectiles on target atoms with atomic numbers ranging from 27 to 90. X-ray production cross sections and energy shifts were measured with Si(Li) detectors. In most cases satisfactory agreement between measurements and theoretical direct ionization cross sections is obtained when the contribution of electron capture is included. The influence of multiple ionization on the fluorescence yield ω K is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01429077
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