ISSN:
1432-1041
Keywords:
prostanoid concentrations
;
plasma
;
gas chromatography/mass spectrometry
;
PGE2
;
PGF2α
;
6-keto-PGF1α
;
TxB2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Plasma concentrations of PGE2, PGF2α, 6-keto-PGF1α and TxB2 were determined in 4 healthy volunteers by gas chromatography-negative ion chemical ionization mass spectrometry. TxB2 concentrations in all volunteers increased with time during blood collection, increases occurred more sporadically in the case of PGE2, PGF2α and 6-keto-PGF1α. Rapid changes in plasma prostanoid concentrations within a sampling series were unpredictable and were inexplicable. The measured plasma prostanoid concentrations apparently depended on the sampling conditions, which could not be adequately standardized and controlled. However, very short term changes in plasma prostanoid levels cannot be excluded.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00981128
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