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  • Articles: DFG German National Licenses  (5)
  • Human circadian rhythm  (2)
  • 78.47. + p  (1)
  • Chemokine  (1)
  • Chemokine receptor  (1)
Source
  • Articles: DFG German National Licenses  (5)
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Femtosecond phase spectroscopy of multi-level systems: Phthalocyanines (1996)
    Springer
    Applied physics 63 (1996), S. 255-264 
    Details
    ISSN: 1432-0649
    Keywords: 07.60.Ly ; 42.65.Re ; 78.47. + p
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A femtosecond frequency-domain interferometer is applied to metal-free and vanadyl phthalocyanine (H2Pc and VOPc) thin films to measure time-resolved difference phase and transmission spectra simultaneously. For both samples, the phase-change dynamics is different from the transmission-change dynamics at 620 nm, reflecting that the phthalocyanines (Pc) cannot be modeled with a two-level system but by a multi-level or inhomogeneously broadened system, in which each level pair exhibits different relaxation dynamics. Because of this dynamical difference, a phase-change measurement is required to correct distortion of the transient spectra due to induced phase modulation of probe pulses. Near zero time delay, the phase and transmission changes show different growth behavior. This behavior is explained by antisymmetric amplitude and phase gratings which are produced by coherent coupling between frequency-chirped pump and probe pulses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01833795
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cytokine upregulation in tubulointerstitial nephritis associated with membranous nephropathy (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 130-132 
    Details
    ISSN: 1437-7799
    Keywords: Key words Tubulointerstitial nephritis ; Membranous nephropathy ; Cytokine ; Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the upregulation of cytokines in a 45-year-old woman with tubulointerstitial nephritis and membranous nephropathy revealed by renal biopsy. She was treated with a combination of prednisolone and cyclosporin. Histological findings showed appreciable improvement, and urinary protein excretion was decreased from 15 g/day to 1 g/day. Elevated urinary levels of chemokines, interleukin (IL)-8 and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein (MCP)-1, and serum levels of tumor necrosis factor (TNF)-α decreased during convalescence; 13 other patients with membranous nephropathy did not show elevation of these cytokines. These results suggest that the upregulation of these cytokines may participate in the pathogenesis of tubulointerstitial nephritis and that combination therapy of prednisolone and cyclosporin may be effective, possibly via inducing a decrease in these cytokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050022
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chemokines: new target molecules in renal diseases (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 273-280 
    Details
    ISSN: 1437-7799
    Keywords: Key words Chemokine ; Chemokine receptor ; Kidney ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presence of leukocytes in the diseased kidneys is a hallmark of almost any kind of renal disease. Activated leukocytes are implicated in playing a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. This study summarizes findings that: (1) chemokine/chemokine receptor systems may be essentially involved in the pathogenesis of phase-specific renal disorders, (2) the measurement of urinary levels of chemokines may be clinically useful for monitoring different disease phases and activities in human renal diseases, and (3) interventions in chemokine/chemokine receptor systems may have potential as particular immunotherapeutic strategies to combat specific phases of renal diseases. Further investigations of anti-chemokine therapies for renal diseases will be required before clinical application is feasible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070001
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phase-dependent shift of free-running human circadian rhythms in response to a single bright pulse (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 1205-1207 
    Details
    ISSN: 1420-9071
    Keywords: Human circadian rhythm ; bright light pulse ; phase-shift ; temporal isolation ; phase response curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Responsiveness of free-running human circadian rhythms to a single pulse of bright light was examined in a temporal isolation unit. Bright light (5000 lx) of either 3 or 6 h duration, applied during the early subjective day, produced phase-advance shifts in both the sleep-wake cycle and the rhythm of rectal temperature; the light pulse had essentially no effect on the phase of the circadian rhythms, when it was introduced during the late subjective day or the early subjective night. The results indicate that bright light can reset the human circadian pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945525
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Entrainment of human circadian rhythms by artificial bright light cycles (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 572-574 
    Details
    ISSN: 1420-9071
    Keywords: Human circadian rhythm ; entrainment ; artificial bright lights ; temporal isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Artificial bright light cycles (LD 8∶16) of about 5000 lux during the light period were applied to two subjects in a temporal isolation unit, who had shown free-running circadian rhythms in sleep-wakefulness and rectal temperature. The circadian rhythms were successfully entrained by the artificial light cycle, but the phase relation of the rhythms to the light cycle was substantially different between the two subjects. The result indicated that the artificial bright lights are able to reset human circadian rhythms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02143589
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    Paper (German National Licenses)
    Fulltext
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