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  • Articles: DFG German National Licenses  (2)
  • ACE-inhibitor  (1)
  • Multiorgan failure  (1)
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  • Articles: DFG German National Licenses  (2)
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Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure (1991)
    Springer
    Intensive care medicine 17 (1991), S. 465-468 
    Details
    ISSN: 1432-1238
    Keywords: Theophylline ; Ethylenediamine ; Pharmacokinetics ; Sepsis ; Multiorgan failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ranging from 10–66% of the value obtained in healthy volunteers. The median t1/2β was 18.8h (range 5.8–25.5) compared to a normal value of 6h. The median clearance of ethylenediamine was 54% of the normal value, while the peripheral volume of distribution was increased to 650%. Due to this t1/2β was 2.3 (2.0–2.7)h, which is 5 times the normal value of 0.55h. There was no correlation between clearance of theophylline and ethylenediamine. As theophylline has a narrow therapeutic range, routine monitoring with measurements of serum theophylline is mandatory in patients with MOF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01690768
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Angiotensin-converting enzyme inhibition as a therapeutic principle in Bartter's syndrome (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 303-305 
    Details
    ISSN: 1432-1041
    Keywords: Bartter's syndrome ; Hypokalaemia ; Captopril ; ACE-inhibitor ; lymphocyte sodium and potassium ; adverse effect ; plasma renin ; aldosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of captopril has been investigated in four patients with Bartter's syndrome treated for 12 weeks. Baseline biochemistry showed normal serum aldosterone (mean 347 pmol·l−1) and a mean serum renin of 217 mU·l−1, and a considerable increase in serum renin during captopril treatment. Serum aldosterone decreased gradually during the study period to about half its initial value. The patients presented with a mean serum potassium of 2.5 mmol·l−1, which rose to 3.4 mmol·l−1 on captopril. Lymphocytes showed a substantial captopril-induced increase in intracellular sodium (from 15 to 22.5 mmol·l−1 on average), but no change in the potassium content. Captopril was well-tolerated. It may be an alternative to potassium-sparing diuretics for maintaining normal serum potassium levels in patients with Bartter's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314956
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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