ISSN:
1432-2307
Keywords:
Amyloid
;
Amyloidosis
;
Amyloid enhancing factor
;
Aging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Amyloid enhancing factor (AEF) activity was tested in spleen homogenates from 52, 28, and 9-week-old untreated mice. Strong AEF activity was present in the supernatant of spleen homogenate from the 52-week-old mice. Only weak activity was observed in the supernatant from the 28-week-old mice, and none was seen in that from the 9-week-old mice. Crude spleen homogenates from the 52-week-old mice were subjected to Sephacryl S-300 gel filtration. AEF activity existed in the first gel filtration peak. These findings suggest that AEF increases in the spleens of aged mice and that AEF may be a substance of high molecular weight.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00781708
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