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  • Articles: DFG German National Licenses  (2)
  • Anaesthesia  (1)
  • Permutation  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Glasgow Coma Scale: variation in mortality among permutations of specific total scores (2000)
    Springer
    Intensive care medicine 26 (2000), S. 157-161 
    Details
    ISSN: 1432-1238
    Keywords: Key words Glasgow Coma Scale ; Outcome ; Permutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The objective of this study was to determine whether different score permutations of the Glasgow Coma Scale (GCS) giving the same GCS total score were associated with significantly different mortality.¶Design: For each GCS total we compared the mortality associated with each of the different GCS permutations using a Fisher's exact test. The relationship between components of the GCS score and mortality was also examined using uni- and multivariate logistic regression.¶Setting: Data were collected from the intensive care unit at Wellington Hospital, a multidisciplinary, tertiary referral unit.¶Patients: We analysed the GCS and mortality data from all admissions over a 4 year period (January 1994–January 1998). Patients with GCS scores of 3 or 15 were excluded, since these two total scores do not have multiple permutations, leaving 1390 patients with GCS scores of 4–14 for analysis.¶Results: The incidence of mortality was significantly different for the different permutations for total GCS scores of 7, 9, 11 and 14.¶Conclusions. It is possible for patients to have the same total GCS score, but significantly different risks of mortality due to differences in the GCS profile making up that score. This suggests that GCS scores may be more useful reported in terms of profiles rather than totals. This could also have implications for the use of other scoring systems such as Acute Physiology and Chronic Health Evaluation and Simplified Acute Physiology Score.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050039
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cardioventilatory coupling in the anaesthetised rabbit, rat and guinea-pig (1999)
    Springer
    Pflügers Archiv 437 (1999), S. 910-916 
    Details
    ISSN: 1432-2013
    Keywords: Key words Cardiorespiratory system ; Anaesthesia ; Rat ; Rabbit ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cardioventilatory coupling is a temporal coherence of respiratory and cardiac rhythms, seen in humans at rest, and during sleep and anaesthesia. In this study we compared the cardioventilatory coupling of anaesthetised rabbits, rats and guinea-pigs. Breathing two successive anaesthetic concentrations (1 or 2% isoflurane) we compared the effect of anaesthetic depth and species on (1) heart rate, (2) heart rate variability, (3) ventilatory rate (f), (4) ventilatory variability, (5) ratio HR/f, (6) degree of coupling (Shannon entropy of the distribution of intervals between inspiration and the preceding electrocardiographic R wave – the RI interval) and (7) coupling pattern, classified into four sub-patterns (I-IV) based upon inspection of the RI interval time series. Rabbits exhibited significantly less ventilatory variability and coupling than rats or guinea-pigs. The sub-pattern of coupling also differed between the three species. Rabbits showed coupling only when HR and f were close to integer ratios whereas other species coupled at non-integer ratios. Ventilatory variability in the rat and guinea-pig differed according to the pattern of coupling observed. Of the three species studied, the rat and guinea-pig demonstrated coupling most similar to that of anaesthetised human subjects. Anaesthetic concentration did not influence the pattern or degree of coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050862
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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