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  • Artikel: DFG Deutsche Nationallizenzen  (4)
  • Analytical Chemistry and Spectroscopy  (2)
  • Ca2+ pump  (1)
  • Column liquid chromatography  (1)
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  • Artikel: DFG Deutsche Nationallizenzen  (4)
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Effect of calmodulin on sarcoplasmic reticular Ca2+-transport in the aging heart (1989)
    Springer
    Molecular and cellular biochemistry 85 (1989), S. 75-791 
    Details
    ISSN: 1573-4919
    Schlagwort(e): aging myocardium ; Ca2+ pump ; sarcoplasmic reticulum ; calmodulin ; Ca2+ uptake
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Heart failure is common among the elderly and an alteration in myocardial Ca2+ transport is believed to be involved in its depressed contractile performance. Although ATP-dependent sarcoplasmic reticular (SR) Ca2+ transport has been reported to decrease in old hearts, virtually nothing appears to be known about the Ca2+ pump activity of SR in aging myocardium in the presence of calmodulin, one of its endogenous activators. In this study, the activity of the Ca2+ pump of aging cardiac SR was assessed in the presence of this endogenous stimulator. This assessment was therefore designed to give additional information about the status of this enzyme in old hearts. Male Sprague-Dawley rats were used and were divided into 3 groups: young (4–6 months old); middle-aged (15–17 months old) and old age (24–25 months old). Purified SR membranes were isolated from ventricular tissues. ATP-dependent Ca2+ accumulation by membrane vesicles of middle-aged and old hearts was significantly depressed in comparison to young hearts at all Ca2+ concentrations employed in the absence and presence of calmodulin. The activity of this Ca2+ transporter was similar in middle-aged and old hearts even in the presence of calmodulin. These results suggest that the activity of the Ca2+ pump in SR of aging hearts is depressed even in the presence of calmodulin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223516
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine (1998)
    Springer
    Chromatographia 47 (1998), S. 264-270 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; NMR and MS detection ; Ibuprofen metabolites ; Urine extracts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The use of HPLC-NMR-MS for the detection and identification of the metabolites of ibuprofen present in a solid phase extract of human urine is described. Gradient reversed-phase HPLC was used to separate the components present in the extract, which were then characterised by a combination of stopped-flow1H NMR and on line electrospray-MS. This approach led to the rapid identification of the known phase 1 human metabolites of ibuprofen, including hydroxy- and carboxy- metabolites, together with their respective glucuronide conjugates. In addition a probable artefact resulting from the dehydration of one of the side chainhydroxylated glucuronides was also identified.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02466530
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    A combined magnetic sector-time-of-flight mass spectrometer for structural determination studies by tandem mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1227-1233 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: A combined magnetic sector-time-of-flight instrument has been constructed and used with both continuous (liquid secondary ion mass spectrometry and electrospray ionization) and pulsed (matrix-assisted laser desorption/ionization) ion sources. The design includes provision for both low- and high-energy gas collision induced decompositions and orthogonal acceleration of the product ions into the time-of-flight mass analyser. Tandem mass spectra may be acquired for singly and multiply charged precursor ions and reliable mass measurements are easily obtained. Product-ion mass spectra are quite reproducible regardless of any instability in the precursor ion beam intensity.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290091302
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Letter to the editor (1992)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 6 (1992), S. 719-720 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290061118
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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