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  • Articles: DFG German National Licenses  (4)
  • stress proteins  (3)
  • Anaplastic centrocytoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Progress in the management of high risk non-Hodgkin's lymphomas (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 619-626 
    Details
    ISSN: 1432-1440
    Keywords: Non-Hodgkin's lymphoma high grade malignancy ; Anaplastic centrocytoma ; Kiel classification ; Symptomatology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of 173 cases of non-Hodgkin's lymphoma (NHL) admitted to our hospital from January 1973 to January 1983 is presented. Of the 173 cases, 124 patients suffered from NHL of high grade malignancy according to the Kiel classification (37 centroblastic lymphoma (CB), 30 immunoblastic lymphoma (IB), 43 lymphoblastic lymphoma (LB), 14 NHL high grade malignancy unclassifiable). In addition, 26 patients with secondary high grade malignant NHL were included in the analysis (14 secondary CB, 10 secondary IB, 2 secondary LB). Also investigated were 23 patients with anaplastic centrocytic lymphoma (CC) (20 primary CC, 3 secondary CC), an entity originally classified as low grade malignant lymphoma, but showing a poor outcome and need for aggressive therapy. Symptoms at presentation of all patients are described. Of the 173 patients, 71% had an advanced stage of the disease at the time of diagnosis (Ann Arbor stage III or IV). B-symptoms were observed in 81%. Extranodal involvement, (exceptive bone marrow involvement), determined by clinical examination was seen in 55%. Survival of patients changed significantly after replacing initial radiotherapy with aggressive chemotherapy (P〈0.001). Improvement of survival statistics was due to the better outcome of patients with localized stages (Ann Arbor stages I and II) as compared to those with generalized disease (P〈0.002). Prognostic factors influencing survival were elevation of lactic dehydrogenase (P〈0.0001) and response to therapy (P〈0.0001). Histological subtypes according to the Kiel classification also showed prognostic relevance. The outcome of patients was significantly influenced by the therapeutic modalities administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732856
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of heat shock proteins, changes in liver ultrastructure, and alterations of fish behavior: are these biomarkers related and are they useful to reflect the state of pollution in the field? (1997)
    Springer
    Journal of aquatic ecosystem stress and recovery 6 (1997), S. 57-73 
    Details
    ISSN: 1573-5141
    Keywords: behavior ; biomarker ; liver ultrastructure ; stream contamination ; stress proteins ; trout
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Heat shock protein (hsp70) expression, changes inliver ultrastructure, and alterations of swimmingbehavior were simultaneously investigated in browntrout (Salmo trutta f. fario) exposed towater from test streams in southern Germany undersemi-field conditions during 1995 and 1996. Chemicalanalyses revealed different levels of contamination ofthe two streams by pesticides, PAHs, PCBs, and heavymetals, whereas stream pollution was only partlyreflected by body burdens of contaminants in fish.Biomarker responses were compared after differenttimes of exposure and with respect to differenttemperature conditions. Differences in pollutionstates of the streams were reflected by differentbiomarker responses of the trout. In the highlycontaminated stream, the biomarker responses were morecoincident with one another than in the moderatelypolluted stream in which the biomarkers showed littlerelation to one another. This is primarily due to thedifferential capacities of the biomarkers to integratestress responses over time. Understanding the dynamicsof the stress response curves and the effects oftemperature on biomarker responses is essential forevaluating the effects of environmental stressors suchas contaminants on the health of organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008224301117
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure: I. Principles and toxicological assessment (1997)
    Springer
    Ecotoxicology 6 (1997), S. 249-262 
    Details
    ISSN: 1573-3017
    Keywords: biomarkers ; heavy metal combinations ; hsp70 ; hsp60 ; isopods ; stress proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The induction of stress-70 (hsp70) and stress-60 (hsp60, chaperonin 60) in the terrestrial woodlouse, Oniscus asellus, after exposure to various heavy metals and heavy metal combinations was investigated by means of standard Western-blot using monoclonal antibodies. The expression of stress-70 was found to react much more sensitively to metal contamination than that of stress-60. The general course of the stress-70 response to increasing metal concentration was found to be similar for all treatments. Based on the obtained results, this course could be divided into three zones: in the first zone, the expression of stress-70 proteins was only marginally increased by comparatively low metal concentrations; in the second zone, strong induction of stress-70 occurred and the ability of the heat shock system to react to increased metal concentrations reached its climax; and in the third, non-compensation zone, a further increase in heavy metal concentration resulted in a decline of stress-70 levels, which can be interpreted as a result of pathological tissue damage. Combinations of metals were found to increase the stress- 70 level more intensely than related concentrations of singularly applied metals. Based on these studies, a ranking scheme of increasing toxicological impact of a variety of heavy metal combinations was composed
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018682928839
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure. II: Joint toxicity and transfer to field situations (1997)
    Springer
    Ecotoxicology 6 (1997), S. 263-274 
    Details
    ISSN: 1573-3017
    Keywords: isobologram ; isopods ; joint toxicity ; hsp70 ; stress proteins ; toxic unit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In laboratory toxicity tests, woodlice (Oniscus asellus) exposed to a variety of different combinations of the metals cadmium, lead, and zinc exhibited a broad range in intensity of the induction of the 70 kDa stress protein (hsp70, stress-70). Using two-dimensional isobolograms and the ‘toxic unit’ concept, it could be shown that cadmium and lead as well as cadmium and zinc or lead and zinc act as synergists and cause superadditive effects on the stress response of these animals. Using a three- dimensional isobologram based on the stress-70 level in response to numerous combinations of all three tested metals, transfer to the field could be achieved: data obtained from O. asellus populations abundant at field sites, the soils of which are influenced mainly by different concentrations of these heavy metals, were found to fit this laboratory test-based model
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018635012910
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    Paper (German National Licenses)
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