ISSN:
1432-2013
Keywords:
Phospholipid Renin Preinhibitor
;
Lysophospholipid Renin Inhibitor
;
Renal Hypertensive Rats
;
Effect on Blood Pressure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary It has been evaluated the effect of acute intravenous administration of a phospholipid renin preinhibitor and its active form (lysophospholipid) in rats rendered hypertensive by unilateral renal ischemia, by continuous infusion of homologous renin and in normal control rats. Both the substances have no effect on blood pressure in normal rats. In rats rendered hypertensive by unilateral renal ischemia or by continuous infusion of homologous renin, injection of inactive phospholipid does not lower blood pressure, while the same quantity of active lysophospholipid brings about a significant reduction. This observation suggest either the absence of circulating specific phospholipase(s), or their non activation of the preinhibitor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00587318
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