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  • Articles: DFG German National Licenses  (3)
  • Antidiuretic hormone  (1)
  • Surgical mesh  (1)
  • affinity chromatography  (1)
Source
  • Articles: DFG German National Licenses  (3)
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biology of the Cell 66 (1989), S. 85-89 
    ISSN: 0248-4900
    Keywords: ADH ; affinity chromatography ; aggregates ; water transport
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1248-9204
    Keywords: Hernia ; Inguinal surgery ; Surgical mesh
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inguinal hernia has been successfully treated using prostheses. However, doubts still remain with regard to tension-free and sutureless techniques, about tension and torsion, wrinkling, prosthesis dislocation and complications in the post-operative phase. We are therefore proposing a new technique, involving the use of a polypropylene prosthesis (Prolene®), known as P.A.D. (Protesi Autoregolantesi Dinamica) which is designed to eliminate these complications. P.A.D. consists of two superimposed layers of surgical mesh. The lower and upper layers of this dynamic prosthesis can move independently from each other, since each is fixed only to one side facing the side of the other layer, allowing for the movement of the aponeurotic and muscular structures. P.A.D. may be used to treat all forms of inguinal hernia in adult males. This study is based on 500 randomly selected male patients with primary inguinal hernias. Excellent results, improved post-operative comfort and recurrence-free follow-up have been observed in all patients treated using this method. There was a significant fall in the consumption of analgesics in the post-operative period, as a result of greater post-operative comfort. P.A.D application is a simple procedure, and is easily replicated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 409 (1987), S. 486-491 
    ISSN: 1432-2013
    Keywords: Water transport ; Antidiuretic hormone ; Urinary bladder ; Forskolin ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study several aspects of the osmotic water-flow-regulation mechanism in frog urinary bladder were examined, utilizing forskolin either as a direct hydrosmotic agent or in association with vasopressin. It was found that forskolin induces a hydrosmotic effect similar to the one induced by vasopressin. This effect is rapid, reversible and dose-dependent. The half-maximally effective concentration (Ec 50 FSK ) is 1.37 μM forskolin. No additional effect on the osmotic water flow was observed when maximal concentrations of forskolin and vasopressin were given simultaneously. Moreover, forskolin can also markedly potentiate vasopressin-induced hydrosmotic response. This potentiation was maximal with submaximal doses of vasopressin, whereas it disappeared when the hormonal concentration was increased to very high levels. Therefore, forskolin increases vasopressin potency without affecting vasopressin efficacy. The Ec 50 FSK′ for the forskolin-induced increase in vasopressin potency was 11 nmol, about two orders of magnitude lower than the Ec 50 FSK for the direct effect of forskolin on the osmotic water transport. On the whole, our results are compatible with a two-site model of forskolin action in frog urinary bladder: a low affinity site (Ec 50 FSK =1.37 μM) that mediates the direct action of forskolin on the osmotic water flow and a high affinity site (Ec 50 FSK′ =11 nmol), which mediates the synergic effect of forskolin with the antidiuretic hormone.
    Type of Medium: Electronic Resource
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