ISSN:
1432-2307
Schlagwort(e):
Bullous skin disorders
;
Immunohistochemistry
;
Antigen presenting cells
;
Langerhans cells
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Skin biopsies from 34 patients, presenting with a variety of bullous skin disorders were investigated, using routine light microscopy and immunohistochemistry. In bullous skin diseases characterized by deposition of complement factors (CF) and/or immunoglobulins (Ig), a monolayer of OKIa 1 + , OKT 6 - , OKM 1 - dendritic cells was found at the dermo-epidermal junction. Retrospectively, these cells were easily recognized on paraffin embedded, H & E stained material. In bullous skin disorders, showing no deposition of CF and/or Ig, this monolayer of dendritic cells was lacking. It is suggested that these OKIa 1 + , OKT 6 - , OKM 1 - dendritic cells at the dermo-epidermal junction represent some type of antigen presenting cells, not corresponding to Langerhans cells, veiled cells or indeterminate cells.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00704299
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