ISSN:
1432-0584
Keywords:
1α, 25-dihydroxycholecalciferol
;
iron
;
Calcium
;
Intestinal absorption
;
Ferritin
;
Iron overload
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Chronic administration of hypercalcemic doses of 1α, 25-dihydroxycholecalciferol to intact, vitamin-D repleted rats for 4 weeks, enhanced net inestinal absorption of iron and liver iron stores. Daily net iron and calcium absorptions were found to be significantly correlated in both control and treated rats. In duodenal loop experiments, pretreatment with 1α, 25-dihydroxycholecalciferol reversed the adverse effect of high Ca/Fe ratio on iron absorption. The increased intestinal absorption of iron did not result in a change of serum iron levels nor of total iron binding capacity due to the enhanced incorporation of absorbed iron into liver ferritin. The curve of uptake of 59Fe into circulating red cells of treated rats suggested retarded release of the isotope from stores. The hypothesis is advanced that the systemic metabolic defect (tissue hypoxia, raised erythropoietin levels) produced by 1α, 25-dihydroxycholecalciferol is responsible for the disruption of the physiological coordination between iron stores and intestinal absorption.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320118
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