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  • Articles: DFG German National Licenses  (5)
  • Aspergillus parasiticus  (2)
  • Hypothalamus  (2)
  • Embolisation
  • 1
    Electronic Resource
    Electronic Resource
    Influence of trace elements and nitrogen sources on versicolorin production by a mutant strain of Aspergillus parasiticus (1979)
    Springer
    Mycopathologia 69 (1979), S. 161-166 
    Details
    ISSN: 1573-0832
    Keywords: Aspergillus parasiticus ; Furobenzofuran ; Versicolorin A ; Versicolorin C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A mutant strain of Aspergillus parasiticus blocked in aflatoxin biosynthesis accumulates versicolorin A and versicolorin C. The effect of trace elements on the growth and versicolorin production by this strain was studied in a defined medium. The omission of manganese was slightly stimulatory to versicolorin production; when zinc was omitted from the medium, no detectable versicolorins were produced. Experiments on nitrogen sources in a highsucrose medium indicated that fourfold to fivefold increases in versicolorin yields could be obtained by substituting 3 ml/l corn steep liquor or 0.1 M NH4NO3 for the 0.023 M (NH4)2SO3 used previously as the nitrogen source in studies on versicolorin production by this strain. These improved yields will facilitate attempts to accumulate enough versicolorin A and versicolorin C for toxicity and carcinogenicity testing. Chromatographic profiles of mycelial extracts of cultures grown in a defined medium with 0.1 M NH4NO3 as the nitrogen source revealed 2 previously unrecognized compounds. The accumulation of these new metabolites in a mutant blocked in aflatoxin production may indicate that they are biosynthetically related to aflatoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452829
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of acetone on production of aflatoxins and versicolorin pigments by resting cell cultures of aspergillus parasiticus (1976)
    Springer
    Mycopathologia 58 (1976), S. 9-12 
    Details
    ISSN: 1573-0832
    Keywords: Aflatoxins ; Versicolorins ; Aspergillus parasiticus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Resting cell cultures of Aspergillus parasiticus were grown in medium containing four different concentrations of glucose, with and without acetone. In addition, the effect of different equimolar concentrations of acetone, acetic acid, ethanol, and sodium acetate was compared at two glucose levels. Aflatoxin and versicolorin pigment production increased in resting cell medium containing increasing concentrations of glucose. In the presence of glucose high concentrations of acetone (1.0 and 0.25 M) inhibited secondary biosynthesis and low concentrations of acetone (0.1, 0.025 and 0.01 M) stimulated secondary biosynthesis of aflatoxins and versicolorin pigments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493586
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Growth and metabolic changes in weanling rats with lesions in the dorsomedial hypothalamic nuclei (1972)
    Springer
    Experimental brain research 15 (1972), S. 424-429 
    Details
    ISSN: 1432-1106
    Keywords: Hypothalamus ; Metabolism ; Growth ; Dorsomedial Nucleus body composition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When compared with sham-operated ad libitum-fed controls, weanling rats with lesions primarily destroying the dorsomedial hypothalamic nuclei (DMNL rats) showed reduced ponderal and linear growth and food intake, normal carcass fat but increased carcass protein. Among the metabolic parameters measured, DMNL rats showed only decreased incorporation of palmitate into epididymal fat pad phospholipid and triglyceride. When sham-operated controls were pair-fed with DMNL rats, they showed growth changes almost identical with those observed in lesioned rats. However, their carcass protein was lower than both that of the lesioned rats and the ad libitum-fed controls. Metabolically, the sham-operated, pair-fed controls showed decreased incorporation of palmitate into triglyceride of epididymal fat pads and decreased oxidation of glucose and increased incorporation into total lipid of the diaphragm. When previous data on growth hormone, insulin, triglyceride and cholesterol are compared with the present findings it is suggested that dorsomedial lesions cause a subcaloric-type dwarfism that does not involve adenohypophyseal secretions and their target organs affecting growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234127
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    N-butyl-2-cyanoacrylate for embolisation of carotid aneurysm (1994)
    Springer
    Neuroradiology 36 (1994), S. 144-147 
    Details
    ISSN: 1432-1920
    Keywords: Aneurysm ; Embolisation ; Endovascular procedures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the use of an N-butyl-2-cyanoacrylate (NBCA) mixture for embolisation of six cases of carotid aneurysm after detachable balloons, and/or microcoils had been placed in the aneurysm. The mixture was injected into the aneurysm to prevent delayed bleeding or distal migration of the balloons, or microcoils. No subarachnoid haemorrhage or distal migration of the balloons or microcoils occurred up to 4.5 years after embolisation. Reflux of the NBCA mixture into the parent artery occurred in one patient, who had a neurological deficit which recovered in a month. NBCA mixture may be useful in embolisation of intracranial or skull base arterial aneurysms, for reducing the size of remaining lumen in an aneurysm at high risk of rebleeding which accommodate no more balloons or microcoils, or preventing possible delayed migration of balloons or microcoils. However, prevention of leakage of the mixture into the parent artery remains a problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588084
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Normal plasma growth hormone levels in growth-retarded weanling rats with dorsomedial hypothalamic lesions (1973)
    Springer
    Experimental brain research 18 (1973), S. 374-382 
    Details
    ISSN: 1432-1106
    Keywords: Growth retardation ; Hypothalamus ; Dorsomedial lesions ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Weanling rats received bilateral electrolytic lesions destroying the areas of the ventromedial (VMN) and dorsomedial (DMN) hypothalamic nuclei, respectively. Trunk blood was collected at sacrifice (Experiment 1 and 2∶ 31 days, Experiment 3∶ 14 days) for the determination of plasma growth hormone (GH) by radioimmunoassay. Rats with DMN lesions showed consistently normal to slightly elevated plasma GH levels while animals with VMN lesions showed significantly reduced plasma GH levels. Linear growth was reduced by both types of hypothalamic lesions but body weight gains and food intake were reduced only in the DMN lesioned rats. Carcass fat was greatly elevated in VMN lesioned rats, moderately elevated in one experiment in the DMN animals and normal in another experiment. These data confirm a previous hypothesis that growth retardation in DMN rats is not due to low circulating GH level but rather represents a hypocaloric-type dwarfism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239106
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    Paper (German National Licenses)
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