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  • Articles: DFG German National Licenses  (2)
  • Atopic dermatitis  (1)
  • Symptoms  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cromones in atopic dermatitis (1980)
    Springer
    Archives of dermatological research 267 (1980), S. 223-228 
    Details
    ISSN: 1432-069X
    Keywords: Atopic dermatitis ; Cromones ; Clinical trial ; Immediate hypersensitivity ; Intra- and epicutaneous tests ; Atopische Dermatitis ; Kromone ; klinischer Versuch ; unmittelbare Hypersensibilität ; intra- und epicutane Tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drei neue Kromone mit einer vermutlich besseren Absorption und einem vermutlich weiteren Spektrum antiallergischer Aktivität als Disodium Cromoglycate wurden untersucht. Die Vorbehandlung mit intradermaler Injecktion von 10 μg FPL 52758 hat in 11 Patienten mit atopischer Dermatitis die durch spezifisches Antigen hervorgerufene ≫weal and flare≪-Reaktion signifikant reduziert. Lokale Applikation von 1,5 mg von FPL 52758 unter Okklusion während 24 h vor ≫challenge≪ hat in denselben Patienten die ≫weal and flare≪-Reaktion nicht reduziert. Der durch die Antigeninjektion verursachte Juckreiz und leichte Schmerz wurde an den mit FPL 52758 vorbehandelten Stellen nicht bemerkt. Vorläufige klinische Erfolge wurden durch Behandlung mit dem Kromone FPL 52757 erhalten. Wegen möglicher Lebertoxicität wurde aber die Untersuchung nicht weitergeführt. Ein ähnliches Kromon ohne Lebertoxicität wurde in einem ≫double-blind within-patient≪-Versuch benutzt, wo 9 Patienten mit minder bis schwachausgeprägter atopischer Dermatitis mit FPL 57787 (5%) Salbe und identischer Grundlage während 4 Wochen ohne signifikante Besserung behandelt wurden.
    Notes: Summary Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 μg FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with atopic dermatitis. The weal and flare reaction was not reduced in the same patients when 1.5 mg of FPL 52758 was applied topically under occulusion for a 24-h period prior to challenge with antigen. The itch and slight pain caused by antigen injection was not experienced in the FPL 52758 pretreated areas. Preliminary clinical results were obtained with the cromone FPL 52757, but due to possible hepatotoxicity this trial was not completed. Another similar cromone without hepatotoxicity was used in a double blind within-patient study. Nine patients with mild to moderate atopic dermatitis were treated with FPL 57787 (5%) ointment and matching placebo ointment. No significant improvement was observed after 4 weeks of treatment with the cromone containing ointment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403843
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Acute and chronic pain syndromes in multiple sclerosis. A 5-year follow-up study (1995)
    Springer
    Neurological sciences 16 (1995), S. 629-632 
    Details
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; Pain ; Symptoms ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'occorrenza di sindromi dolorose acute (durata inferiore a 1 mese) o croniche (durata superiore a 1 mese) è stata indagata in 49 pazienti (22 maschi e 27 femmine) con sclerosi multipla definita. Ciascun paziente è stato esaminato due volte con un intervallo di 5 anni tra i due controlli. Tra il primo e il secondo controllo si è osservato un significativo aumento di sindromi dolorose acute e croniche comprendenti tensione e dolore alle estremità, spasmi, lombalgia, segno di Lhermitte e dolori neuralgici. Tale aumento si è verificato sia nei maschi che nelle femmine ed è particolarmente evidente nei pazienti con deterioramento e disabilità.
    Notes: Abstract Forty-nine (22 males, 27 females) patients with definite multiple sclerosis were examined twice with 5 years interval regarding acute (less than 1 month duration) and chronic (more than 1 month duration) pain syndromes. From the first to the second examination a significant increase was found in the number of acute and chronic pain syndromes, including tension and pain in the extremities, spasms, low back pain, Lhermitte's sign and neuralgia. The increase included both men and women. The increase was especially found in patients with deterioration of disability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230913
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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