ISSN:
1432-0428
Keywords:
Type 1 diabetes
;
B cell function
;
C-peptide
;
glycaemic control
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Within 24h of diagnosis, 15 consecutive Type 1 (insulin-dependent) diabetic patients were allocated at random to one of two treatment groups: group A (n=9, mean age: 28 years, range: 17–35 years) was treated conventionally with one or two daily doses of insulin; group B (n=6, mean age: 27 years, range: 21–37 years) was treated with nine daily injections of fast-acting insulin for ten days and thereafter conventionally as for group A. The mean diurnal blood glucose concentration during the initial ten days of insulin treatment was 11.7±0.5mmol/l (mean±SEM) in group A and 6.4±0.3 mmol/l in group B (p〈0.01). Pancreatic B cell function was evaluated 1, 7, 14, 90, and 180 days after the start of insulin treatment from the C-peptide response to a standard meal. At one and seven days after diagnosis, no difference was found in B cell function between the two groups. After 14 days, the amount of C-peptide secreted during the test meal was 18.0±2.6 nmol (mean±SEM) in group A compared with 29.0+3.6 nmol in group B (p〈0.05). After 90 and 180 days, no difference was demonstrated in B cell function. The maximal B cell function observed was similar in the two groups, but occurred earlier in group B (at 14 days) than in group A (at 90 days) (p〈0.05). This study indicates that strict initial glycaemic control may lead to an earlier improvement in B cell function, but that this improvement is of short duration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00253863
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