ISSN:
1432-069X
Keywords:
Key words Basal cell carcinoma cell line
;
Keratinocyte
;
IL-1α
;
IL-1β
;
IL-6
;
IL-8
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A basal cell carcinoma (BCC) cell line (BCC-1/KMC) has recently been successfully established from a patient. The production of interleukin-1· (IL-1·), IL-1‚, IL-6 and IL-8 was assessed in comparison with that of cultured normal keratinocytes. The mRNA expression of these cytokines was measured by a reverse transcriptase-polymerase chain reaction (RT-PCR) method and the protein production by an ELISA. The cultured BCC cells spontaneously secreted more IL-6 and IL-8 but less IL-1 than the keratinocytes after culture for 24 h at 37° C. It is suggested that the increased expression of IL-6 and IL-8 may indicate the transformation of normal keratinocytes to locally aggressive BCC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004030050039
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