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  • Articles: DFG German National Licenses  (2)
  • Biochemistry and Biotechnology  (1)
  • Garuga gamblei  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Molecular similarity analysis on biologically active macrocyclic bis(bibenzyls) (1996)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 9 (1996), S. 133-138 
    Details
    ISSN: 0952-3499
    Keywords: macrocyclic bis(bibenzyls) ; molecular similarity ; marchantin A ; ricrardin A ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Conformational analysis of marchantin A (1), a bis(diarylether) type, and riccardin A (2), a diarylether-biphenyl type macrocyclic bis(bibenzyl) was carried out by systematic unbounded multiple minimum search (SUMM). Mobility of the macrocyclic rings was analysed by variable temperature 1H-NMR study. Molecular similarity analysis was performed on the minimum energy conformers of 1 and 2 comparing their steric, electrostatic and hydrophobic properties. Correlation between complexation properties and calmodulin inhibitor activity was established. Differences in steric and electrostatic profiles may be responsible for the reduced Ca2+ affinity and activity of 2.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Synthesis of Garugamblin-2, a Macrocyclic Diarylheptanoid Constituent of Garuga gamblei (1994)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1994 (1994), S. 361-364 
    Details
    ISSN: 0170-2041
    Keywords: Garugamblin-2 ; Diarylheptanoids ; Macrocycles ; Garuga gamblei ; Calculations, MMX, PM3 ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The macrocyclic diarylheptanoid garugamblin-2 (1) and its constitutional and sterical isomers 17-19 were synthesized using the isoxazole derivative 8 for the introduction of the β-methoxyenone function. Ring closure was accomplished by an intramolecular Wittig reaction.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199419940408
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    Paper (German National Licenses)
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