Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (2)
  • Biochemistry and Biotechnology  (1)
  • SYMPTOMS  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 43 (1998), S. 2715-2718 
    ISSN: 1573-2568
    Keywords: IRRITABLE BOWEL SYNDROME ; SYMPTOMS ; FREQUENCY ; DURATION ; SEVERITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined symptom frequency, duration, andseverity, as well as episode patterns, in 122 adultpatients with irritable bowel syndrome in a 12-weekstudy conducted in the United States, the UnitedKingdom, and The Netherlands. Patients used aninteractive telephone data entry system daily to reportsymptoms. Data from 59 of the patients meeting inclusioncriteria are presented, the remainder having beenexcluded for failing to complete at least 70 days ofsymptom reporting. The majority of patients experiencedat least one symptom on over 50% of the reported days;however, individual symptoms were reported on less than 50% of the days, indicating that symptomssometimes occurred sequentially rather than alwayssimultaneously. On average, patients reportedpain/discomfort on 33% of days, bloating on 28% of thedays, altered stool form or stool passage on 25% and18% of the days, respectively, and mucus on 7% of thedays. The duration of symptoms was relatively short,with pain/discomfort and bloating lasting the longest, an average of five days each per episode. Allsymptoms but one (mucus) were moderately severe on themajority of reported days. Patients experienced an“episode” (defined as a period of days withsymptoms bounded by one or more symptom-free days) on anaverage of 12.4 times during the study, but the durationof these episodes varied greatly among patients. Theseresults further establish the chronic nature of irritable bowel syndrome and the burden thatthis condition imposes on patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 9 (1996), S. 211-218 
    ISSN: 0952-3499
    Keywords: vitamin K-dependent proteins ; γ-carboxyglutamic acid ; vitamin K-dependent proteins ; γ-carboxyglutamic acid ; calcium-binding proteins ; immunoaffinity ; pseudoaffinity ; protein C ; protein S ; factor X ; pseudoaffinity ; pseudoaffinity ; prothrombin ; factor IX ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: There are seven known vitamin K-dependent proteins in blood. These proteins require calcium ion for expressing their full biological activities. Calcium ion also induces conformational changes in this class of proteins. Taking advantage of the ligand induced conformational changes, a number of unique approaches of affinity chromatography have been developed. These methodologies have been very useful tools for both the purification and for understanding the structure-function relationships of this class of proteins. One method is the use of metal ion dependent immunoaffinity chromatography. The antigen can be dissociated from the antibodies with either the removal or addition of calcium ion under physiological conditions. The other method is pseudoaffinity chromatography. This method uses conventional ion-exchange or hydrophobic resin and manipulates the mobilities of the proteins on these resins by the presence or absence of calcium ions. Researchers working with other calcium binding proteins or other proteins that are known to undergo ligand induced conformational changes may benefit from the experience of these unique conformation-specific affinity chromatography approaches.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...