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  • Articles: DFG German National Licenses  (2)
  • Birth asphyxia  (1)
  • Leukotriene  (1)
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  • Articles: DFG German National Licenses  (2)
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Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Perirolandic hypoperfusion on single-photon emission computed tomography in term infants with perinatal asphyxia: comparison with MRI and clinical findings (2000)
    Springer
    Neuroradiology 42 (2000), S. 908-912 
    Details
    ISSN: 1432-1920
    Keywords: Key words Cerebral palsy ; Birth asphyxia ; Magnetic resonance imaging ; Single-photon emission computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the findings on single-photon emission computed tomography (SPECT) in patients with perinatal asphyxia at term, with perirolandic cortico-subcortical changes on MRI, and to correlate them with clinical features. SPECT of 7 patients was obtained after injection of 185–370 MBq of Tc-99m-ECD (ethyl cysteinate dimer). The patients had spastic quadriplegia (7/7) with perinatal asphyxia (6/7) at term (7/7). The results were correlated with the MRI findings. Hypoperfusion of the perirolandic cortex was clearly seen on SPECT in all patients, even in two with subtle changes on MRI. SPECT demonstrated a more extensive area of involvement than MRI, notably in the cerebellum (in 4), the thalamus (in 7) and basal ganglia (in 5), where MRI failed to show any abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340000357
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of leukotrienes and prostaglandins on cochlear blood flow in the chinchilla (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 479-483 
    Details
    ISSN: 1434-4726
    Keywords: Key words Cochlear blood flow ; Prostaglandin ; Leukotriene ; Laser Doppler flowmeter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prostaglandins (PGs) such as PGE2 and PGI2 are vasodilators, and leukotrienes (LTs) such as LTB4 and LTC4 are vasoconstrictors. Our previous studies have shown that salicylate ototoxicity is associated with decreased levels of PGs and increased levels of LTs. We hypothesized that vasodilating PGs increase cochlear blood flow and vasoconstricting LTs decrease cochlear blood flow. PGE2, Iloprost (a PGI2 analog), LTB4, and LTC4 were applied to the round window membranes of chinchillas and cochlear blood flow was measured with a laser Doppler flowmeter. PGE2 increased cochlear blood flow, while LTC4 decreased cochlear blood flow. This findings show that vasodilating PGs may have therapeutic implications for sensorineural hearing loss and/or vertigo by increasing cochlear blood flow. Vasoconstricting LTs may cause hearing loss by decreasing cochlear blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050195
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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