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  • Articles: DFG German National Licenses  (2)
  • Bremazocine  (1)
  • Fentanyl  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects (1983)
    Springer
    Psychopharmacology 81 (1983), S. 224-227 
    Details
    ISSN: 1432-2072
    Keywords: Discriminative stimulus ; Fentanyl ; Morphine ; Ethanol ; Tetrahydropapaveroline ; Salsolinol ; 3-Carboxysalsolinol ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgestic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these data do not support a biochemical link between ethanol and opiates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427266
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of narcotic and non-narcotic drugs in rats trained to discriminate opiate ϰ-receptor agonists (1982)
    Springer
    Psychopharmacology 78 (1982), S. 63-66 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Ethylketocyclazocine ; Bremazocine ; Nalorphine ; Pentazocine ; Buprenorphine ; Etorphine ; Dextrorphan ; Phencyclidine ; Ketamine ; Haloperidol ; Diazepam ; Pentobarbital ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to evaluate the discriminative stimulus properties of some narcotic and nonnarcotic drugs in rats trained to discriminate the effect of the proposed opiate ϰ-receptor agonists ethylketocyclazocine and bremazocine. Male Sprague-Dawley rats were trained in a two-lever food-reinforced paradigm to discriminate between the effect of ethylketocyclazocine (0.32 mg/kg) or bremazocine (0.04 mg/kg) and saline. Both groups of trained rats showed dose-dependent generalization to the effect of the proposed ϰ-agonist MRZ-2033 and some animals generalized the effect of nalophine and pentazocine. Some ethylketocyclazocine — but no bremazocine — trained rats generalized the effect of buprenorphine. The effect of dextrorphan, phencyclidine, and ketamine was generalized by some bremazocine-, but no ethylketocyclazocine-trained rats. Neither group of rats generalized the effect of etorphine, haloperidol, diazepam, or pentobarbital. These data suggest the usefulness of this procedure to evaluate the ϰ-like properties of opioid drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470590
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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