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  • 1
    Electronic Resource
    Electronic Resource
    Monitoring of hematopoietic recovery after autologous stem cell transplantation by analysis of G alpha 16 mRNA and CD34 surface glycoprotein (1998)
    Springer
    Annals of hematology 76 (1998), S. 153-158 
    Details
    ISSN: 1432-0584
    Keywords: Key words Gα16 ; CD34 ; Hematopoietic recovery ; Autologous stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The hematopoiesis-specific G protein alpha subunit Gα16 was shown to be expressed in early normal and malignant hematopoietic cell lines and has been suggested to play an important role in signal transduction of hematopoiesis. We previously demonstrated a strict correlation of Gα16 mRNA and CD34 antigen expression in peripheral blood stem cells (PBSC). In PBSC mobilization, both markers are detectable at the time of hematopoietic recovery and progenitor cell release. In this study the possible use of Gα16 determination in peripheral blood samples for monitoring patients undergoing stem cell transplantation was investigated. Normal peripheral blood is negative for Gα16 expression. In all five patients Gα16 mRNA expression appeared shortly before the time of blood cell recovery. When tested together with CD34 (three cases) a pattern different from CD34 antigen expression was found, reflecting a different mechanism of action. In two cases with different time points of leukocyte and platelet recovery Gα16 mRNA was detected at both time points but not in the interval, thus suggesting a role of Gα16 in multipotent precursor cells. CD34 mRNA tested in three patients was not detected at any time; this argues for different regulation of CD34 and Gα16 mRNA. Gα16 may be used as an indicator of hematopoietic recovery after autologous stem cell transplantation, suggesting that there are cell type-specific G protein-mediated signal transduction pathways of early hematopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050380
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure: I. Principles and toxicological assessment (1997)
    Springer
    Ecotoxicology 6 (1997), S. 249-262 
    Details
    ISSN: 1573-3017
    Keywords: biomarkers ; heavy metal combinations ; hsp70 ; hsp60 ; isopods ; stress proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The induction of stress-70 (hsp70) and stress-60 (hsp60, chaperonin 60) in the terrestrial woodlouse, Oniscus asellus, after exposure to various heavy metals and heavy metal combinations was investigated by means of standard Western-blot using monoclonal antibodies. The expression of stress-70 was found to react much more sensitively to metal contamination than that of stress-60. The general course of the stress-70 response to increasing metal concentration was found to be similar for all treatments. Based on the obtained results, this course could be divided into three zones: in the first zone, the expression of stress-70 proteins was only marginally increased by comparatively low metal concentrations; in the second zone, strong induction of stress-70 occurred and the ability of the heat shock system to react to increased metal concentrations reached its climax; and in the third, non-compensation zone, a further increase in heavy metal concentration resulted in a decline of stress-70 levels, which can be interpreted as a result of pathological tissue damage. Combinations of metals were found to increase the stress- 70 level more intensely than related concentrations of singularly applied metals. Based on these studies, a ranking scheme of increasing toxicological impact of a variety of heavy metal combinations was composed
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018682928839
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure. II: Joint toxicity and transfer to field situations (1997)
    Springer
    Ecotoxicology 6 (1997), S. 263-274 
    Details
    ISSN: 1573-3017
    Keywords: isobologram ; isopods ; joint toxicity ; hsp70 ; stress proteins ; toxic unit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In laboratory toxicity tests, woodlice (Oniscus asellus) exposed to a variety of different combinations of the metals cadmium, lead, and zinc exhibited a broad range in intensity of the induction of the 70 kDa stress protein (hsp70, stress-70). Using two-dimensional isobolograms and the ‘toxic unit’ concept, it could be shown that cadmium and lead as well as cadmium and zinc or lead and zinc act as synergists and cause superadditive effects on the stress response of these animals. Using a three- dimensional isobologram based on the stress-70 level in response to numerous combinations of all three tested metals, transfer to the field could be achieved: data obtained from O. asellus populations abundant at field sites, the soils of which are influenced mainly by different concentrations of these heavy metals, were found to fit this laboratory test-based model
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018635012910
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of heat shock proteins, changes in liver ultrastructure, and alterations of fish behavior: are these biomarkers related and are they useful to reflect the state of pollution in the field? (1997)
    Springer
    Journal of aquatic ecosystem stress and recovery 6 (1997), S. 57-73 
    Details
    ISSN: 1573-5141
    Keywords: behavior ; biomarker ; liver ultrastructure ; stream contamination ; stress proteins ; trout
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Heat shock protein (hsp70) expression, changes inliver ultrastructure, and alterations of swimmingbehavior were simultaneously investigated in browntrout (Salmo trutta f. fario) exposed towater from test streams in southern Germany undersemi-field conditions during 1995 and 1996. Chemicalanalyses revealed different levels of contamination ofthe two streams by pesticides, PAHs, PCBs, and heavymetals, whereas stream pollution was only partlyreflected by body burdens of contaminants in fish.Biomarker responses were compared after differenttimes of exposure and with respect to differenttemperature conditions. Differences in pollutionstates of the streams were reflected by differentbiomarker responses of the trout. In the highlycontaminated stream, the biomarker responses were morecoincident with one another than in the moderatelypolluted stream in which the biomarkers showed littlerelation to one another. This is primarily due to thedifferential capacities of the biomarkers to integratestress responses over time. Understanding the dynamicsof the stress response curves and the effects oftemperature on biomarker responses is essential forevaluating the effects of environmental stressors suchas contaminants on the health of organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008224301117
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    Paper (German National Licenses)
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