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Enzymatic esterification of bixin by l-ascorbic acid (2000)

Humeau, C. ; Rovel, B. ; Girardin, M.

Springer

Biotechnology letters 22 (2000), S. 165-168

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ISSN: 1573-6776

Keywords: Ascorbyl ester ; bixin ; Candida antarctica ; lipase B ; norbixin ; transesterification

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Notes: Abstract Bixin, a carotenoid, was esterified by l-ascorbic acid using immobilized lipase B from Candida antarctica. The conversion of l-ascorbic acid was 25% under atmospheric pressure. Ester production was twice higher when working under reduced pressure and was third lower when norbixin was used as a substrate-acyl donor due to lipase specificity, leading to a conversion of l-ascorbic acid of 50% and 8%, respectively.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1005665913685

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Ultrastructural aspects of nerves, bones, and vessels in hereditary sensory neuropathy (1985)

Teot, L. ; Arnal, F. ; Humeau, C. ; [et al.]

Hoboken, NJ [u.a.] : Wiley-Blackwell

Journal of Orthopaedic Research 3 (1985), S. 226-235

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ISSN: 0736-0266

Keywords: Hereditary sensory neuropathy ; Bone resorption ; Osteoclasts ; Vascular reflex ; Life and Medical Sciences

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine

Notes: This study concerns two children, from the same otherwise normal family, presenting progressive spontaneous amputations of the limbs, suggesting peripheral hereditary sensory neuropathy. Samples from the distal nerves and vessels and the distal tibial epiphyses were examined ultrastructurally. The nerves showed signs of degeneration, and a typical bone necrosis, without osteoclasts, was observed in the 2 cm margin of the samples. Simultaneous modifications of the vessels suggest a neurally initiated vascular reflex resulting in bone destruction. Theories that might explain the observations are discussed.

Additional Material: 10 Ill.