ISSN:
1619-7089
Keywords:
Gastric emptying
;
Technetium-99m
;
Carboxymethylcellulose
;
Fibre marker
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report a study of technetium-99m-labelled carboxymethyl-cellulose (99mTc-CMC) as a newly developed non-digestible marker of the solid phase of gastric contents. The radiosynthesis is simple and shows a high labelling efficiency. In vitro and in vivo experiments demonstrated stability of the marker in the gastrointestinal tract during the process of gastric emptying. The gastric half-emptying time in ten healthy volunteers of both sexes was 105 ± 17 min (mean ± SD). This rate of gastric emptying is similar to that of non-digestible solid-phase markers such as in vivo labelled99mTc-chicken liver or radio-iodinated cellulose. In comparison with digestible solid-phase markers such as99mTc-labelled pancake or99mTc-cooked egg, gastric emptying of99mTc-CMC occurred more slowly, confirming the expected behaviour of a non-digestible solid-phase marker. We conclude that99mTc-CMC has the advantage of a simple and rapid labelling procedure and may be useful for clinical studies of gastric emptying.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02258427
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