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  • Articles: DFG German National Licenses  (3)
  • Carotenogenesis  (1)
  • Key words: Sarcoidosis—Tumor necrosis factor receptor—Lymphocyte—Bronchoalveolar lavage  (1)
  • X-ray structure of trinuclear Ru(H) complex: asymmetric hydrogenation  (1)
Source
  • Articles: DFG German National Licenses  (3)
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of cationic trinuclear BINAP-Ru(II) complexes: crystal structure of [Ru"3Cl"5((S)-binap)"3]BF"4
    Amsterdam : Elsevier
    Tetrahedron Letters 32 (1991), S. 3101-3104 
    Details
    ISSN: 0040-4039
    Keywords: BINAP ; Ru(II) complex ; X-ray structure of trinuclear Ru(H) complex: asymmetric hydrogenation ; homogeneous catalysis.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-4039(91)80700-G
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Elevated Levels of Type II Soluble Tumor Necrosis Factor Receptors in the Bronchoalveolar Lavage Fluids of Patients with Sarcoidosis (1997)
    Springer
    Lung 175 (1997), S. 187 -193 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Sarcoidosis—Tumor necrosis factor receptor—Lymphocyte—Bronchoalveolar lavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Since tumor necrosis factor (TNF) is known to be involved in granuloma formation in sarcoidosis, and soluble TNF receptors (sTNF-Rs) inhibit TNF action in vivo, we evaluated the levels of sTNF-Rs in the bronchoalveolar lavage fluids (BALF) of 31 subjects using an enzyme-linked immunosorbent assay. Our group consisted of 13 patients with sarcoidosis (7 sarcoidosis patients who received no treatment and 6 who received corticosteroid therapy) and 18 control subjects (11 healthy nonsmokers and 7 asymptomatic smokers). Type II (75-kDa), but not type I (55 kDa) sTNF-R in BALF was elevated significantly in patients with sarcoidosis compared with the healthy nonsmokers (type I: 126.7 ± 17.6 pg/ml BALF vs 79.4 ± 16.5 pg/ml BALF, p 〉 0.05; type II: 98.3 ± 27.8 pg/ml BALF vs 26.7 ± 4.9 pg/ml BALF, p 〈 0.05). Although levels of type I sTNF-R in BALF from sarcoidosis patients were not correlated with any cellular profiles of BALF, concentrations of type II correlated significantly with the numbers of lymphocytes in BALF. We concluded that sTNF-R is a normal constituent of the epithelial lining fluids and that levels of type II sTNF-R are elevated significantly in the BALF from individuals with sarcoidosis. This suggests that sTNF-Rs may influence the local bioactivity of TNF and may also contribute to the pathogenesis of sarcoidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007566
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Carotenoid synthesis in Streptomyces setonii ISP5395 is induced by the gene crtS, whose product is similar to a sigma factor (1995)
    Springer
    Molecular genetics and genomics 247 (1995), S. 387-390 
    Details
    ISSN: 1617-4623
    Keywords: Streptomyces setonii ISP5395 ; Cryptic gene ; Carotenogenesis ; Sigma factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In many species of actinomycetes, carotenogenesis can be photoinduced. The capacity to respond to photoinduction is, however unstable and, in various strains of Streptomyces, is lost at a relatively high frequency. In Streptomyces setonii ISP5395, which normally produces no carotenoids, carotenoid-producing mutants can be obtained following protoplast regeneration. We report here the characterization of a gene, crtS, which was isolated from one such mutant and can confer on wild-type S. setonii ISP5395 cells the capacity to synthesize carotenoids. Sequence analysis of crtS reveals an open reading frame, which shows homology to genes that encode alternative sigma factors in Bacillus subtilis. We propose that crtS encodes a sigma factor which is necessary for the expression of a cryptic gene(s) for carotenoid biosynthesis in S. setonii ISP5395.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293207
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    Paper (German National Licenses)
    Fulltext
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