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  • Articles: DFG German National Licenses  (2)
  • Cartilage  (1)
  • Hazard analysis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints (1999)
    Springer
    Rheumatology international 18 (1999), S. 183-191 
    Details
    ISSN: 1437-160X
    Keywords: Key words Arthritis ; Synovium ; Cartilage ; Gene expression ; Tissue inhibitors of metalloproteinases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathophysiological and biological significance of tissue inhibitor of the metalloproteinases-3 (TIMP-3) gene compared to other TIMPs was investigated in osteoarthritic (OA) human and normal bovine joint tissues. Human OA synovial fibroblasts in culture constitutively expressed TIMP mRNAs. TIMP-3, TIMP-1 and gelatinase A mRNAs were elevated in most human OA synovia over controls, while TIMP-2 expression was similar. TIMP-3 and TIMP-1 mRNAs present in bovine cartilage were inducible by serum factors. Transforming growth factor beta (TGF-β1) induced TIMP-3 RNA and protein in human OA and normal bovine chondrocytes. TIMP mRNAs were low (TIMP-1) or undetectable in human fetal chondrocytes but were expressed at all other ages. Thus, the two main joint tissues, synovial membranes and cartilage, express TIMP genes. Due to their matrix protecting activities, the presence of multiple TIMPs may be beneficial for normal joints, while increased TIMP-3 and TIMP-1 expression in arthritic joints may be associated with pathological remodeling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960050083
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Seismic hazard analysis for the Philippines (1988)
    Springer
    Natural hazards 1 (1988), S. 27-44 
    Details
    ISSN: 1573-0840
    Keywords: Hazard analysis ; risk analysis ; seismic zoning ; probabilistic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Two sample probabilistic hazard maps for the Philippine Region are compiled. In these are shown various levels of expected horizontal ground acceleration for some given annual probability of exceedence, namely, for 0.1% a.p.e. and for 0.01% a.p.e. Such hazard maps are needed by structural engineers for compiling seismic zoning maps. The hazard maps are derived from source-zone or seismogenic maps, which, in turn, are compiled from seismographic, geologic, and geotectonic data. Much weight is put on geotectonic data rather than on seismographic data. The former lends support to extrapolating to much longer periods of ‘exposure time’ or longer periods of recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168220
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    Paper (German National Licenses)
    Fulltext
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