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  • Articles: DFG German National Licenses  (6)
  • Cataract  (2)
  • cataracts  (2)
  • ivermectin  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 88 (1994), S. 285-293 
    ISSN: 1573-2622
    Keywords: Ultraviolet-B ; Ocular exposure ; Cataract ; Pterygium ; Risk assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although an association between UV-B exposure and ocular damage has been long suspected, this relationship is still not well quantified. Cataract is the most significant ocular damage associated with UV-B exposure. Initial studies of the association between UV-B exposure and cataract were hampered by a lack of precision in the assessment of cataract and a failure to separate cataract types. With a few exceptions, most studies have not assessed individual ocular UV-B exposure but have used ambient levels or isolated behaviours. Ecologic studies show there is more cataract in sunny areas, but whereas ambient UV-B fluxes may change by a factor of 3 or 4 over the globe, individual behaviour can change ocular exposure in a given location by 20-fold or more. The Chesapeake Bay Watermen studies assessed individual ocular UV-B exposure and have shown a consistent relationship between exposure to UV-B and the risk of both cortical and posterior subcapsular cataract. However, further work to refine these findings is sorely needed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 88 (1994), S. 307-325 
    ISSN: 1573-2622
    Keywords: Cataract ; Latitude ; Sunlight ; Epidemiological analysis ; Ultraviolet ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For many years, it has been suggested that exposure to sunlight, particularly its ultraviolet component, may be associated with an increased risk of senile cataract. This paper adresses 1) the physical and geographic variables that affect the entry of ultraviolet light in the eye; 2) the epidemiologic evidence that associates cataract with ultraviolet light exposure; and 3) the effectiveness of personal barrier protection (i.e. sunglasses and hats) in reducing ocular exposure to ultraviolet light. The epidemiologic evidence is drawn from studies in Australia, China, Tibet, and the United States. The U.S evidence consists of data from the Maryland Watermen study and analyses of cataract surgery under the Medicare program which provides health insurance for nearly all Americans age 65 and over (30 million) and pays for 85% of the 1.3 million cataract extractions performed annually in the U.S. Analysis of the Medicard data shown that, after controlling for age, sex, and race, and income of the population and also controlling for supply of ophthalmologists, optometrists, price of surgery and local practice costs, the strongest predictor of cataract surgery likelihood in a Medicare benificiary is the person's latitude of residence. Latitude correlates directly with the UV-B content of sunlight, because the incident angle of the sun determines the atmospheric penetration of ultraviolet radiation. Data suggest that the probability of cataract surgery in the U.S. increases by 3% for each 1 degree decrease (i.e. more Southerly) in latitude.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 11 (1987), S. 83-85 
    ISSN: 1573-2630
    Keywords: onchocerciasis ; treatment ; ivermectin ; vector control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America. Although a large-scale vector control program has been highly successful in limiting transmission of infection in West Africa, there has not been a satisfactory form of treatment available for those already infected or those living in other areas. Despite the fact that two drugs, diethylcarbamazine and suramin, are active against the filarial parasite that causes onchocerciasis, their use is severely limited by their toxicity and the reaction they induce. A newly developed drug, ivermectin, appears to offer a major revolution in the treatment of onchocerciasis. In a series of clinical trials, ivermectin has been shown to be an extremely effective microfilaricide which induces only minimal side effects. Ivermectin is given as a single oral dose which can be repeated on an annual basis. In view of its safety and efficacy and its ease of administration, it seems likely that ivermectin will be suitable for use in mass chemotherapy programs against onchocerciasis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 14 (1990), S. 189-194 
    ISSN: 1573-2630
    Keywords: onchocerciasis ; blindness ; ivermectin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Onchocerciasis is a devastating blinding disease caused by the parasite Onchocerca volvulus that infects about 80 million people, causing blindness and visual impairment in 1–2 million people. In hyperendemic areas, more than half of the population will become blind from onchocerciasis before they die. Blindness is the most important effect of the disease and results, in part, from direct invasion of the eye by microfilariae. The recent development of ivermectin has revolutionized our ability to treat this disease. An annual oral dose of only 150 mg/kg completely suppresses the disease manifestations. Programs for the community-based mass distribution of ivermectin are now being conducted and promise to control this major blinding scourge.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 15 (1991), S. 123-129 
    ISSN: 1573-2630
    Keywords: blindness ; cataracts ; corneal opacity ; Tanzania ; trachoma ; visual impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A population-based survey of the prevalence of major blinding disorders was conducted in three villages in central Tanzania. Overall, 1827 people overthe age of seven years old were examined. In those age seven and older, the prevalence of bilateral blindness (visual acuity in the better eye of 〈3/60) was 1.26% and monocular blindness (visual acuity of 〈3/60 in one eye) was 4.32% and the prevalence of visual impairment (visual acuity 〈6/18 but ≥3/60 in both eyes was 1.04% and in one eye was 1.75%. Corneal opacities were responsible for 44% of bilateral and 39% of monocular blindness and resulted from trachoma, measles often in association with Vitamin A deficiency, keratoconjunctivitis, and the use of traditional eye medicines. Cataracts accounted for 22% of bilateral and 6% of monocular blindness. Readily preventable or reversible causes of blindness were responsible for 65% of cases of bilateral and 46% of monocular blindness.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 15 (1991), S. 123-129 
    ISSN: 1573-2630
    Keywords: blindness ; cataracts ; corneal opacity ; Tanzania ; trachoma ; visual impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A population-based survey of the prevalence of major blinding disorders was conducted in three villages in central Tanzania. Overall, 1827 people overthe age of seven years old were examined. In those age seven and older, the prevalence of bilateral blindness (visual acuity in the better eye of 〈3/60) was 1.26% and monocular blindness (visual acuity of 〈3/60 in one eye) was 4.32% and the prevalence of visual impairment (visual acuity 〈6/18 but ≥3/60 in both eyes was 1.04% and in one eye was 1.75%. Corneal opacities were responsible for 44% of bilateral and 39% of monocular blindness and resulted from trachoma, measles often in association with Vitamin A deficiency, keratoconjunctivitis, and the use of traditional eye medicines. Cataracts accounted for 22% of bilateral and 6% of monocular blindness. Readily preventable or reversible causes of blindness were responsible for 65% of cases of bilateral and 46% of monocular blindness.
    Type of Medium: Electronic Resource
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