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  • Articles: DFG German National Licenses  (11)
  • Cell & Developmental Biology  (7)
  • Collusion  (2)
  • Keratinocyten  (2)
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  • Articles: DFG German National Licenses  (11)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of vitamin A acid on cyclic nucleotides of cultured keratinocytes (1980)
    Springer
    Archives of dermatological research 267 (1980), S. 25-31 
    Details
    ISSN: 1432-069X
    Keywords: Vitamin A acid ; Keratinocytes ; Cyclic nucleotides ; Thymidine incorporation ; Cell cycle ; Vitamin A-Säure ; Keratinocyten ; cyclische nukleotide ; Thymidinaufnahme ; Cellcyclus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Primärkulturen von Meerschweinchenohr-Keratinocyten wurden mit Vitamin A-Säure behandelt zum Zeitpunkt des Ansetzens der Kulturen oder 14 h bzw. 14 Tage danach. In einem Zeitraum bis 50 h nach Behandlung wurde die intracelluläre Konzentration von den cyclischen Nukleotiden cAMP und cGMP mit einem Radio-Immunoassay in Intervallen bestimmt. Wenn die Zugabe der Vitamin A-Säure beim Ansetzen der Kulturen erfolgte, resultierte eine Welle von DNA-Synthese und eine Zunahme der DNA-Konzentration, die ihre Maxima zwischen 30 und 40 h nach Kulturansatz erreichte und zeitlich mit einer Abnahme der cAMP-Konzentration zusammenfällt. Dies könnte auf eine Keratinocyten-Subpopulation hinweisen. Die Zugabe von Vitamin A-Säure 14 h oder 14 Tage nach Kulturansatz führte zu sofortiger, wenn auch zeitlich begrenzter Abnahme der cAMP- und cGMP-Konzentration sowie einer Welle von Thymidin-Aufnahme die nicht mit einer Zunahme des DNA-Gehalts in der Petrischale verbunden war. Somit wirkt eine einmalige Behandlung mit Vitamin A-Säure nur dann Mitoseauslösend, wenn deren zugabe beim Ansetzen der Zellkultur erfolgte. Zu späteren Zeitpunkten verursacht Vitamin A-Säure Veränderungen in der Konzentration der cyclischen Nukleotide ohne bemerkbare Zellproliferation.
    Notes: Summary Primary cultures of guinea pig ear keratinocytes were treated with vitamin A acid at plating, or at 14 h or 14 days after plating. The intracellular content of the cyclic nucleotides cAMP and cGMP was determined by radioimmunoassay at intervals during a period of 50 h after treatment. When added at plating, vitamin A acid produced a wave of DNA synthesis and increase in DNA which was at maximum between 30 and 40 h after plating, and coincided with decreased cAMP levels. This may represent a subpopulation of keratinocytes in S phase. Treatment with vitamin A acid at 14 h or 14 days after plating resulted in an immediate but temporary fall in cAMP and cGMP, and a wave of thymidine uptake but no increase in DNA per dish. Thus, a single treatment with vitamin A acid is mitogenic only when applied at plating. At other times, it can cause changes in cyclic nucleotide content without any observable cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416918
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of methylglyoxal bisguanylhydrazone on polyamine biosynthesis, growth, and differentiation of cultured keratinocytes (1980)
    Springer
    Archives of dermatological research 269 (1980), S. 61-68 
    Details
    ISSN: 1432-069X
    Keywords: Polyamines ; Keratinocytes ; Differentiation ; Methylglyoxal bisguanylhydrazone ; Psoriasis ; Polyamin ; Keratinocyten ; Differenzierung ; Methylglyoxal bisguanylhydrazone ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Putrescin-, Spermidin- und Spermingehalt in Subkulturen von menschlichen Vorhaut-Keratinocyten wurde während der Phase des schnellen Wachstums und der frühen Plateau-Phase bestimmt. Der höchste Wert wurde in der Wachstums-Phase gefunden. Zugabe von Methylglyoxal bis(guanylhydrazone) während der Wachstums-Phase resultierte in einer konzentrationsabhängigen Abnahme des intracellulären Spermidin- und Spermingehaltes und bei hoher Konzentration Zunahme des Putrescingehaltes. Diese Wirkungen reflektieren die Hemmung der S-adenosyl methionine Decarboxylase durch Methylglyoxal bis(guanylhydrazone). Eine Konzentration dieser Substanz von 8×10-6 M reduzierte den Einbau von radioaktivem Leucin in Eiweiß, reduzierte oder verhinderte die Ansammlung von DNA per Petrischale, inhibierte die mitotische Aktivität und erhöhte den Histidin/Leucin Einbau in Eiweiß. Letztere Wirkung wird als Induzierung der Epithelisierung angesehen. Alle diese Wirkungen waren reversibel, wenn die Inhibitor-Substanz nach 3 Tagen abgewaschen wurde. Hemmung der Enzyme der Polyamin Biosynthese können möglicherweise in der Psoriasistherapie wertvoll sein.
    Notes: Summary The putrescine, spermidine, and spermine content of subcultured human newborn foreskin keratinocytes was determined during growth and early plateau phase and found to be highest during growth. Exposure of the cells to methylglyoxal bis(guanylhydrazone) during growth phase caused a dose-dependent fall in intracellular spermidine and spermine levels and an increase in putrescine levels at higher concentrations. These effects reflect inhibition of S-adenosyl methionine decarboxylase by the drug. At 8×10-6 M the drug reduced incorporation of leucine into protein, lowered or stopped the accumulation of DNA per dish, inhibited mitotic activity, and increased the histidine/leucine incorporation into protein. The last effect is regarded as induction of keratinization. All these effects were reversible if the use of the drug was discontinued after 3 days. Inhibition of the enzymes of polyamine biosynthesis may have value in psoriasis therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404458
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Efficiencyv. collusion: Evidence cast in cement (1994)
    Springer
    Review of industrial organization 9 (1994), S. 379-392 
    Details
    ISSN: 1573-7160
    Keywords: Collusion ; efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Through the 1970s and 1980s, the U.S. portland cement industry experienced a significant increase in average plant size and market concentration. A simultaneous equation model is developed to examine the effects of plant size and concentration on costs, prices and margins in that industry. The results indicate the presence of significant scale economies, but also show that prices and margins are increasing in concentration. Further analysis shows that almost one third of the cost savings associated with larger plants are passed on to producers through higher margins resulting from concomitant increases in concentration, rather than to consumers as lower prices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01029512
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    CooperationV. Rivalry and factors facilitating collusion (1994)
    Springer
    Review of industrial organization 9 (1994), S. 823-838 
    Details
    ISSN: 1573-7160
    Keywords: Collusion ; conjectures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract A perennial topic in industrial economics is collusion. Kwoka and Ravenscraft (1986) developed a model to measure the collusiveness of conjectures across industries as a function of intra-industry rivalry among leading firms. But extensive literature suggests that the degree of collusion may also depend upon underlying market characteristics. We modify the Kwoka and Ravenscraft model to account for this. Our results suggest that underlying market characteristics do matter. Intra-industry rivalry and conjectures vary with the level and stability of concentration, and to a lesser degree with product homogeneity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01026587
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Monoclonal Antibodies Which Alter the Morphology of Cultured Chick Myogenic Cells (1982)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 18 (1982), S. 221-229 
    Details
    ISSN: 0730-2312
    Keywords: monoclonal antibodies ; myogenesis ; cell surface ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells poorly attached to the substratum. The effects of both antibodies are reversible. Fab fragments of JG22 can cause the morphological change. A tentative identification of the antigen recognized by JG22 is made.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.1982.240180209
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Functional and structural changes of rat plantaris motoneurons following compensatory hypertrophy of the muscle (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 229 (1991), S. 129-137 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The conduction velocity and histological structure of motoneurons innervating normal and hypertrophied rat plantaris muscles were investigated. Hypertrophy was produced by ablation of synergist muscles. Single motor units were obtained by ventral root dissection and conduction velocities measured. The structure of neurons was investigated following retrograde labeling with horseradish peroxidase. A combined silver, gold and cholinesterase staining method was developed to study the motor endplate. In addition, the peripheral nerve was fixed, embedded in Araldite, and sectioned for determination of axonal size and myelin thickness. Conduction velocity of motor axons decreased following hypertrophy of the skeletal muscle (control CV = 75.8 ± 8.9 m s-1, n = 94, hypertrophy CV = 69.0 ± 12.3 m s-1, n = 84). However, no alteration in the size of motor axons or myelin thickness could account for this alteration in conduction velocity. Mean motoneuronal soma size decreased following muscle hypertrophy (soma diameter: control 36.1 ± 4.6 μ, n = 283, hypertrophy 32.9 ± 4.5 μ, n = 294). The complexity of the motor endplate increased following hypertrophy with an increased occurrence of nodal sprouts. In addition, the area of cholinesterase staining increased following hypertrophy (control 588.1 ± 297.2 μm2, n = 269, hypertrophy 857.7 ± 357.0 μm2, n = 269). This study found that both the morphological and physiological parameters of motoneurons innervating a hypertrophied muscle were shifted toward those of normal rat slow motor units.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092290115
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The coronary blood supply in the cat (1933)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 58 (1933), S. 25-30 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1090580104
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  • 8
    Electronic Resource
    Electronic Resource
    The atrioventricular conduction system of the beef heart (1931)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 49 (1931), S. 167-192 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1000490202
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis and secretion of immunoglobulin G by lymphocytes from cultured mouse spleen cells is not affected by heat shock (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 135 (1988), S. 145-150 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Short-term hyperthermic episodes (in vivo and in vitro) alter gene expression in mammalian lymphocytes, resulting in the enhanced synthesis of a select group of polypeptides - the heat-shock proteins - and the depressed synthesis of many normally synthesized polypeptides. Such alterations could have profound implications to an individual if the appropriate functioning of lymphocytes within the immune response was compromised by a depression in immunoglobulin synthesis during naturally occurring periods of hyperthermia, such as fever. In the present study we asked if heat-shock affects the facultative synthesis and secretion of immunoglobulin G by cultured mouse lymphocytes. We found that the quantity of immunoglobulin G synthesized and secreted by these cells is not affected by heat-shock treatments sufficient to induce the synthesis of heat-shock proteins.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041350121
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    From embryonal carcinoma cells to neurons: The P19 pathway (1994)
    New York, NY : Wiley-Blackwell
    BioEssays 16 (1994), S. 343-348 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct-3 and Brn-2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950160509
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