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  • Cerebellum  (1)
  • Ganglioneuroblastoma  (1)
  • Tissue Culture of Chick Spinal Cord  (1)
  • Ultrastructure  (1)
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Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Neurotoxic effects of 6-aminonicotinamide on cultures of central nervous tissue (1973)
    Springer
    Acta neuropathologica 26 (1973), S. 259-264 
    Details
    ISSN: 1432-0533
    Schlagwort(e): 6-Aminonicotinamide ; Tissue Culture of Chick Spinal Cord ; Electron Microscopy ; Neurotoxic Effects ; Glucose-6-Phosphate Dehydrogenase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Well myelinated cultures of chick embryo spinal cord were exposed to medium containing 6-aminonicotinamide in a concentration of 0.5 mmol for up to 48 h. By 24–48 h of exposure to the antivitamin, neurons showed a granulovacuolar degeneration which later led to the formation of large vacuoles in the neuronal perikarya. Myelin degeneration was also observed in this period in the form of swelling, beading and ballooning. Electron microscopy revealed moderately swollen mitochondria and dilated endoplasmic reticulum as the earliest neuronal change. Later, neurons became pyknotic and the cytoplasmic organelles disintegrated. Presynaptic endings and glial cells, however, was spared any degenerative change. Intermittent and irregular splitting of myelin lamellae were also observed along the intraperiod lines. Biochemical assay of the glucose-6-phosphate dehydrogenase activity in the experimental cultures showed that 45% of the enzyme activity was lost during the 30-h period. It is concluded that the formation of 6-aminonicotinamide analogues of NAD and NADP coenzymes leads to the impairment of the pentose phosphate pathway and the glucose turnover, and thus produces neurotoxic effects in the central nervous system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00684436
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  • 2
    Digitale Medien
    Digitale Medien
    Observations on cerebellar granule cells in tissue culture (1970)
    Springer
    Cell & tissue research 107 (1970), S. 454-465 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Cerebellum ; Neuron ; Synapses ; Myelin sheath ; Tissue culture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary In long-term organized cultures of newborn mouse cerebellum, granule cell neurons were studied with silver impregnation and electron microscopy. In silver impregnated cultures, small neurons are defined as granule cell neurons from their size, morphology and location. There are also occasional large nerve endings with the morphology typical of mossy fiber endings. In correlative electron micrographs, granule cell neurons revealed a faithful reproduction of characteristic structures seen in vivo. The fine structural details of cerebellar glomeruli and myelinated granule cell bodies developed in vitro were also described.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00335434
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  • 3
    Digitale Medien
    Digitale Medien
    Neuronal differentiation of human neuroblastoma SH-SY5Y cells by gangliosides (1997)
    Springer
    Brain tumor pathology 14 (1997), S. 5-11 
    Details
    ISSN: 1861-387X
    Schlagwort(e): Gangliosides ; Neuronal differentiation ; Neuroblastoma ; Ganglioneuroblastoma ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Exogenous administration of gangliosides induced neuronal differentiation with prominent neuritogenesis in human neuroblastoma SH-SY5Y cells in vitro. Neuritogenesis was characterized by ruffling of the cell membrane, the development of lamellipodia and filopodia, and the subsequent elongation and branching of the neurites ultrastructurally. Both axons and neurites were identified. Increased numbers of cell organelles in the neurites and cell bodies were noted. Nonsynaptic contacts and gap junctions formed between neurites or between each neurite and cell body. These findings could be implicated in histopathologic changes from neuroblastoma to ganglioneuroblastoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02478862
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