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  • Articles: DFG German National Licenses  (3)
  • Cerebral blood flow  (1)
  • Cerebral ischaemia  (1)
  • Circadian rhythm  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cerebral blood flow in moyamoya disease (1990)
    Springer
    Acta neurochirurgica 105 (1990), S. 30-34 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral blood flow ; moyamoya disease ; internal carotid artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study has been made of the cerebral blood flow (CBF) in moyamoya disease from the perspective of hemispheric cerebral blood flow and regional CBF (rCBF). The material includes 21 children between the ages of 5 and 15 years with moyamoya disease, and 19 adult moyamoya cases-all of which had virtually no neurological symptoms at the time of the study. CBF was measured using the133Xe intravenous injection method. Comparsion was made with the measurements from 16 normal children and 14 normal adults. Study was also made of the relationship between the angiographic stage of the disease and the CBF. With the exception of the more elderly patients, CBF was found to be significantly lower in the moyamoya cases than in normal subjects of the same age group. In all age groups, the distribution of rCBF showed a dominant posterior distribution, dissimilar to the dominant anterior distribution found in the normals. Among the juvenile moyamoya cases, there was a tendency toward decreasing hemispheric blood flow together with advancing disease-as determined angiographically. Moreover, with advancing stages of the disease, there was a continuing transition from the normal pattern of frontal dominance to one of occipital dominance. This dominance of posterior rCBF is thought to be a characteristic feature of moyamoya disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01664854
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of proximal vertebral artery stenosis (1991)
    Springer
    Acta neurochirurgica 112 (1991), S. 13-18 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; vertebral artery reconstruction ; vertebral to subclavian transposition ; vertebrobasilar insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For vascular reconstruction in cases of atherosclerotic stenosis at the origin of the vertebral artery, we use vertebral to subclavian artery transposition. We discuss the advantages and effectiveness of such treatment based on a study of 32 cases. We have experienced neither surgical mortality nor morbidity and the outcome at the time of discharge has been favourable. Follow-up revealed no deaths, however, three cases exhibited symptoms of cerebral ischaemia. One had a supratentorial completed stroke, and the other two hat TIA or RIND, but without any notable lesion in the angiograms. There were no cases of cerebral infarction of the posterior fossa. We believe that this method should be the first choice for treatment of cases without lesions of the subclavian artery for the following reasons: serious operative complications have not been encountered, surgical invasion is minimal, temporary occlusion of the common carotid artery is unnecessary, the operation can be done by occluding only the vertebral artery, and unlike various bypass operations, anastomosis is required at only one location and is consequently technically uncomplicated. Following anastomosis the cerebral blood pathway is physiological.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402448
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chronopharmacological study of neuroleptics (1979)
    Springer
    Psychopharmacology 63 (1979), S. 131-135 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Circadian rhythm ; Sedative effect ; Antiapomorphine effect ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429690
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    Paper (German National Licenses)
    Fulltext
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