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  • Articles: DFG German National Licenses  (2)
  • Chemical carcinogen  (1)
  • Gliomas  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localisation of macromolecules of the basement membrane and extracellular matrix of human gliomas and meningiomas (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 245-252 
    Details
    ISSN: 1432-0533
    Keywords: Collagens ; Fibronectin ; Laminin ; Gliomas ; Meningiomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of type I, III, IV and V collagen in 35 gliomas and 20 meningiomas was studied by indirect immmunofluorescence staining. In addition, the presence of fibronectin (FN) and laminin (LN) is also reported. In gliomas expression of type IV collagen and LN was found in the vessel walls and associated with the endothelial glomerulus-like proliferations. FN and type V collagens were located in proliferating vessel walls in a pattern corresponding both to the basement membrane and the perivascular matrix around the vessels. In the extracellular matrix of grade III and IV gliomas occasional faint intercellular fluorescence was also observed with both FN and type V collagen. Type I and III collagens were localised in the vessel walls and in the perivascular connective sheet. Glioma cells did not express any of the antigens investigated. In meningiomas, type IV and V collagens, LN and FN were found in vessel walls, whorls formations and psammoma bodies. These stainings support the hypothesis of a vascular origin of these psammoma bodies which were only found in syncytial and transitional meningiomas. Both type I and III collagens were detected in the perivascular connective tissue. In general, meningioma cells and extracellular matrix did not express any of these molecules, except in transitional meningiomas where occasional fluorescence was observed in extracellular matrix with type V collagen and FN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688590
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Aspect ultrastructural des lesions induites au niveau du poumon de souris par le N-nitroso-N-methylurethane (1972)
    Springer
    Journal of cancer research and clinical oncology 77 (1972), S. 279-291 
    Details
    ISSN: 1432-1335
    Keywords: Lung mouse tumors ; Chemical carcinogen ; Ultrastructure ; Pneumocyte II ; Crystalline inclusions ; Interstitial fibrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The pulmonary tumours induced in Swiss mice by NMUR seem to be constituted for the most part by cells closely related to the granular pneumocytes (pneumocytes II ou B). Other rarer cells, of epithelial bronchiolar aspect, may take part in the proliferation. The ultrastructural study of tumoral cells suggest that their secretory functions are disturbed. The origin of the crystalline intratumoral structures is discussed, as well as their possible relationship with the production of surfactant. The peritumoral areas are characterized by a dense interstitial flbrosis in which the collagen fibers are associated with an elastoid substance.
    Notes: Resumé Les tumeurs pulmonaires induites chez la souris swiss par le NMUR apparaissent essentiellement constituées de cellules apparentées aux pneumocytes granuleux (pneumocytes II ou B). D'autres cellules plus rares, de morphologie épithéliale bronchiolaire peuvent participer á la prolifération. L'étude ultrastructurale des cellules tumorales suggère que leurs fonctions secrétoires sont perturbées. Le mode de formation des structures cristallins intratumorales est discuté, ainsi que leur rapport éventuel avec la production du surfactant. Les territoires péri-tumoraux sont caractérisés par une fibrose interstitielle dense où les fibres de collagène sont associées à uns substance élastoïde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283971
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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