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  • Articles: DFG German National Licenses  (4)
  • Children  (2)
  • Ketol-isomerization  (2)
  • 1
    ISSN: 1434-4475
    Keywords: Ketol-isomerization ; Tricyclic diterpene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The syntheses of the pleuromutilin derivatives12 and16 are described. Both compounds on treatment with base rearrange to the isomeric ketol13. The results of the deuteration experiment as well as the kinetic measurements are in agreement with the hypothesis of an intramolecular 1,4-hydride shift.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-4475
    Keywords: Pleuromutilin ; Ketol-isomerization ; 11,2-Hydride-shift ; 1,2-Carbonyl-transposition ; Photoaddition to enones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract 2-Hydroxy-19,20-dihydropleuromutilin (10) undergoes a stereospecific ketolisomerisation when treated with base under phase/transfer conditions (11, 12). The subsequent reductive elimination of the 3-acetoxygroup afforded mutilin with a 1,2-transposed ketofunction (13).
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Kulturvergleichende Analyse ; Child Behavior Checklist ; Verhaltensauffälligkeiten ; Kinder ; Jugendliche ; Key words Cross cultural study ; Child Behavior Checklist ; Behavior problems ; Children ; Adolescents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The goal of the study was a cross-cultural comparison of the parent ratings of behavior problems of children and adolescents aged 4–18 years in Germany, The Netherlands and the United States using the Child Behavior Checklist (CBCL). The analyses were undertaken in a German community sample (n = 1622) and a Dutch community sample (n = 2076). The results were compared with the data published by Achenbach for the national US sample. The analyses were based on the scales of the 1991 CBCL version and were performed for four age and sex groups (4- to 11-year-old boys/girls and 12- to 18-year-old boys/girls). In general, relatively minor differences could be detected between the three random samples. The range in the different samples was between –0.04 and 0.35, which is in line with other cross-cultural analyses using the CBCL. As long as no representative norms for Germany are available, the American norms can serve as an orientation for German studies using the CBCL.
    Notes: Zusammenfassung Ziel der Studie ist eine kulturvergleichende Analyse der Beurteilungen von Verhaltensauffälligkeiten von Kindern und Jugendlichen im Alter von 4 bis 18 Jahren durch ihre Eltern in Deutschland, den Niederlanden und den USA anhand der Child Behavior Checklist (CBCL). Die Analysen werden in einer deutschen Feldstichprobe (n = 1622) und einer niederländischen Feldstichprobe (n = 2076) durchgeführt und mit den von Achenbach [1] publizierten Daten für die nationale US-Stichprobe verglichen. Basis der Analysen ist die Skalierung der CBCL in der Version von 1991. Die Analysen werden für vier Alters- und Geschlechtsgruppen (4- bis 11 jährige Jungen/Mädchen und 12- bis 18 jährige Jungen/Mädchen) durchgeführt. Insgesamt lassen sich nur relativ geringfügige Unterschiede zwischen den 3 Stichproben nachweisen. Die mittleren Effektstärken schwanken in den einzelnen Stichproben zwischen –0,04 und 0,35. Damit werden andere kulturvergleichende Analysen mit der CBCL bestätigt, in denen ebenfalls überwiegend geringfügige Kultureffekte nachgewiesen wurden. Solange noch keine für die Bundesrepublik repräsentative Stichprobe vorliegt, kann eine Orientierung an der amerikanischen Normierung erfolgen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 17 (1991), S. 209-214 
    ISSN: 1432-1238
    Keywords: Hypoxemia ; Children ; Adult respiratory distress syndrome ; Combined high-frequency ventilation ; PEEP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six children conventionally ventilated for acute pulmonary parenchymal failure developed severe hypoxemia (mean PaO2 48±7 mmHg at an FiO2 of 0.95±0.08) persisting for more than 6 h despite a progressive increase in positive end expiratory pressure (PEEP) to 14.7±1.5 cmH2O. Combined high-frequency jet ventilation (HFJV, mean rate 225 b/min superimposed on small tidal volume conventional ventilation) resulted in a sustained increase in PaO2 to 93±21 mmHg,p〈0.05 while peak inspiratory pressure decreased from 47±8 to 35±6 cmH2O and positive end expiratory pressure could be reduced to 5.8±4.5 cmH2O,p〈0.05 and FiO2 to 0.88±0.10. This improvement occurred without new barotrauma nor deleterious effects on hemodynamic function or diuresis. After a mean of 62 h of combined HFJV, persistant improvement in gas exchange allowed us to resume conventional mechanical ventilation at lower airway pressures in 4 children who continued to improve and survived. The 2 other children maintained satisfactory gas exchange on combined HFJV, but ultimately died from multiple organ failure. We conclude that combined HFJV might prove helpful to relieve profound hypoxemia and possibly decrease the risk of barotrauma in children with catastrophic pulmonary failure.
    Type of Medium: Electronic Resource
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