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Digitale Medien

Successful treatment of chronic idiopathic neutropenia using recombinant granulocyte colony-stimulating factor (1991)

Furukawa, Tatsuo ; Takahashi, Masuhiro ; Moriyama, Yoshiaki ; [weitere]

Springer

Annals of hematology 62 (1991), S. 22-24

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ISSN: 1432-0584

Schlagwort(e): Chronic idiopathic neutropenia ; Granulocyte colony stimulating factor ; Subcutaneous injection

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A patient with chronic idiopathic neutropenia, who had been suffering from repeated infections, was successfully treated with recombinant granulocyte stimulating factor (rhG-CSF). Subcutaneous injection of 30μg/m2 rhG-CSF every two days was sufficient to maintain the neutrophil count at approximately 1,000/μl. The patient has lived without any evidence of infection for the last 10 months using that treatment. There were no side effect caused by rhG-CSF and antibodies against G-CSF were not detected in the patient's plasma.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01714979

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Digitale Medien

Experimental rat model representing both acute and chronic heart failure related to autoimmune myocarditis (1995)

Koyama, Sen ; Kodama, Makoto ; Izumi, Tohru ; [weitere]

Springer

Cardiovascular drugs and therapy 9 (1995), S. 701-707

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ISSN: 1573-7241

Schlagwort(e): autoimmune myocarditis ; heart failure ; hemodynamics ; dobutamine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The most important clinical manifestation of myocarditis is congestive heart failure. The precise mechanisms of heart failure during myocarditis have not been elucidated because no animal model that would permit in vivo study of hemodynamics in severe active myocarditis has been available. We monitored hemodynamics and left ventricular function in a rat model of experimental autoimmune myocarditis to determine if this model could be useful for the study of in vivo hemodynamics in severe active myocarditis. Lewis rats were immunized with human cardiac myosin suspended in complete Freund's adjuvant. Baseline hemodynamics were measured using an ultraminiature catheter pressure transducer via the right internal carotid artery, 4 weeks after immunization in one group of rats (acute phase) and 3 months after immunization in another group (chronic phase). Untreated rats served as the control group. Hemodynamic measurements were also obtained after infusion of dobutamine in the acute-phase and chronic-phase groups. The heart weight-to-body weight ratios were significantly higher in both the acute-phase group and the chronic-phase group compared with normal control rats. The baseline left ventricular systolic pressure was significantly lower in the chronic phase group than in the control group. Peak dP/dt and peak -dP/dt were significantly lower in both the acute-phase group and the chronic-phase group compared with the control group. Dobutamine significantly increased left ventricular systolic pressure, peak dP/dt, and peak -dP/dt in the chronic-phase group but caused only minor changes in hemodynamic variables in the acute-phase group. In vivo measurements of hemodynamic variables indicated the presence of left ventricular dysfunction in rats with experimental autoimmune myocarditis. This animal model may be useful for the study of both acute heart failure related to acute myocarditis and chronic heart failure due to diffuse myocardial fibrosis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00878553

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