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  • 1
    Electronic Resource
    Electronic Resource
    Microsatellite instability: new aspects in the carcinogenesis of colorectal carcinoma (1995)
    Springer
    Virchows Archiv 426 (1995), S. 215-222 
    Details
    ISSN: 1432-2307
    Keywords: Colorectal carcinoma ; Hereditary non-polyposis colonic cancer ; Microsatellite instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Very recently a new molecular mechanism in the tumorigenesis of colorectal carcinoma has been described which is closely linked to hereditary non-polyposis colonic cancer (HNPCC). Ubiquitous changes in the length of simple repetitive DNA sequences between constitutional and tumour DNA occur in about 90% of cases of HNPCC and in about 15% of cases of non-familial, sporadic colorectal carcinoma. Such microsatellite instabilities have been shown to be the phenotypical marker of mutations in the human homologues of prokaryotic mismatch repair genes (MutS, MutL, MutH). These data provide crucial new tools in the detection of patients at high risk of developing colon cancer and other HNPCC-related carcinomas. In addition, these developments provide new insights into a new, presumably primary event in oncogenesis, i.e. the occurrence of mutations in genomic stability genes leading to an increased cellular mutation rate (“mutator phenotype”) and thus to cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191357
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas (1999)
    Springer
    Archives of dermatological research 291 (1999), S. 1-5 
    Details
    ISSN: 1432-069X
    Keywords: Key words Microsatellite instability ; Loss of ; heterozygosity ; Keratoacanthomas ; Kaposi’s sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Variations in the length of simple repetitive tandem repeats (microsatellite instability, MIN) between constitutive and tumour DNA, which is characteristic of tumours in patients affected with hereditary nonpolyposis colon cancer (HNPCC), have been found to be very important in the carcinogenesis of a variety of human neoplasms. Recently, MIN has been found in sebaceous and colorectal tumours as well as in keratoacanthomas of Muir-Torre syndrome. In order to elucidate the significance of both MIN and loss of heterozygosity (LOH) in the pathogenesis of sporadic keratoacanthomas, the presence of MIN and LOH at five loci [chromosome 5q21 (D5S346, APC), 9p21 (D9S171, p16), 10pter (D10S89, Mfd28), 11p (D11S904) and 17p12 (D17S520, p53)] was evaluated. MIN was found at only one locus (p53) in 1 of 12 keratoacanthomas and no evidence for the presence of LOH could be detected. Our results suggest that, in contrast to keratoacanthomas associated with Muir-Torre syndrome, neither MIN nor LOH appear to be significant in the induction of sporadic keratoacanthomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050376
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    Paper (German National Licenses)
    Fulltext
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