ISSN:
1432-2072
Keywords:
Psychopharmacology
;
Flupenthixol
;
Flupenthixol-Decanoate
;
Mice
;
Methylphenidate
;
Apomorphine
;
Compulsive Behaviour
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract α-Flupenthixol and α-flupenthixol decanoate were tested in mice against methylphenidate-induced stereotyped gnaw-compulsions. The effect of both α-flupenthixol, and α-flupenthixol decanoate disappeared 2 days after administration. In addition, the influence of α-flupenthixol and α-flupenthixol decanoate on the apomorphine-induced behaviour in mice was followed over a period of 12 days. Under these conditions apomorphine-induced compulsive gnawing was seen on the days on which the methylphenidate antagonistic effect had subsided. The apomorphine-induced compulsive gnawing seen in α-flupenthixol and α-flupenthixol decanoate pretreated animals could be antagonized by additional small doses of α-flupenthixol given 2 h before apomorphine. The interference of the neuroleptic drugs with dopaminergic receptors is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421936
Permalink
