ISSN:
1432-1106
Keywords:
Neuronal transplantation
;
Cyclosporin A
;
Cross-species
;
Dopamine neurons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237035
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