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  • Articles: DFG German National Licenses  (2)
  • Cytomegalovirus infection  (1)
  • Growth Hormone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Neuroendocrine effects of apomorphine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: Relations to psychopathology and tardive dyskinesia (1984)
    Springer
    Psychopharmacology 84 (1984), S. 436-440 
    Details
    ISSN: 1432-2072
    Keywords: Chronic schizophrenics ; Long-term neuroleptic therapy ; Neuroleptic withdrawal ; Growth Hormone ; Prolactin ; Psychopathology ; Tardive Dyskinesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free period were significantly elevated (13.1±12 ng/ml) as compared to NL therapy (4.6±6.1 ng/ml). Controls showed a significant higher mean peak GH response (13.6±10 ng/ml) compared to chronic schizophrenic patients under long-term NL therapy. The GH response of patients with symptoms of tardive dyskinesia (TD) did not differ significantly from that of patients without signs of TD. The prolactin (PRL) serum levels under long-term NL treatment were within the normal range in male schizophrenics but decreased significantly after 12 days' drug withdrawal. The data presented indicate a reduced sensitivity of the hypothalamic-pituitary dopamine receptors under long-term NL therapy. The significant increase in GH response on day 12 probably corresponds to a readjustment from a mostly blunted GH response under NL therapy back to stimulated levels of normal controls. No supersensitivity of the pituitary dopamine recpetors could be detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555228
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary tamm-horsfall protein as a marker of renal transplant function (1994)
    Springer
    Urological research 22 (1994), S. 131-136 
    Details
    ISSN: 1434-0879
    Keywords: Kidney transplantation ; Tamm-Horsfall protein ; Acute tubular necrosis ; Rejection episodes ; Cytomegalovirus infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a total of 428 urine samples collected from 15 patients aged between 23 and 60 years after cadaveric kidney transplantation during a postoperative hospital stay, Tamm-Horsfall protein (THP) was quantitatively determined using theELIAS SYNELISA-THP immunoassay. All patients were treated with azathioprine, cyclosporine, prednisolone, given an intraoperative high-dose single antilymphocyte globulin bolus and discharged with functioning grafts. In clinically uncomplicated courses, even after immediate transplant function, the recovery of graft function took on average 7 days. Thereafter the urinary THP excretion was relatively stable and amounted, on average, to 14.5 ± 4.9 mg/24 h (i.e. was at the lower limit of normal urinary THP excretion). In cases of delayed onset of graft function of undetermined origin accompanied by extremely reduced urinary THP excretion, the functional recovery, whether spontaneous or brought about by treatment, was characterized by a continuous increase in urinary THP excretion. In connection with interstitial rejections urinary THP excretion seems not to be a recommendable diagnostic parameter. Daily measurement of urinary THP is, however, suitable for monitoring the functional state of transplanted kidneys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571838
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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