ISSN:
1432-0428
Keywords:
Type 1 (insulin dependent) diabetes
;
North Indian Asians
;
HLA-DR typing
;
DQβ
;
DQα
;
DRβ-gene probing
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Genetic associations with Type 1 (insulin-dependent) diabetes may be primary or secondary to linkage disequilibrium. Studies of different racial groups should allow these to be distinguished. We have reported that Type 1 diabetes is associated with HLA-DR3 and -DR4 in subjects of North Indian (Punjab) origin and now present the results of a study of HLA class II DNA polymorphisms in this group and in white caucasoid subjects. DR4 in North Indian Type 1 diabetic patients was associated with DQβ and DXα DNA polymorphisms identical to those found in DR4-positive white caucasoid patients. This DQβ/DXα pattern was increased in frequency in North Indian diabetic patients vs control subjects (33.3% vs 8.5%,p〈0.001, relative risk=5.12 (95% confidence limits: 1.96–13.4)). A DQβ polymorphism with very low relative risk for Type 1 diabetes in white caucasoid subjects was also markedly reduced in North Indian diabetic patients vs control subjects (2.3% vs 24.7%,p〈0.02, relative risk = 0.10 (95% confidence limits: 0.02–0.46)). This pattern was associated with DR2 in white caucasoid subjects, but with DRw6 in North Indians. A DR3-associated DRβ polymorphism was markedly increased in North Indian diabetic patients vs control subjects (90.2% vs 40.7%,p〈10−6, relative risk = 12.1 (95% confidence limits: 4.32–33.9)). The DQ subregion may be a primary site of genetic influence on susceptibility to Type 1 diabetes. Further studies in different racial groups will clarify the HLA associations of Type 1 diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02341501
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