ISSN:
1432-1912
Keywords:
GABA
;
Benzodiazepines
;
Inhibition
;
Diazepam
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of diazepam was evaluated on spontaneous activity and drug-and electrically-elicited inhibitions of neuronal activity. Doses of diazepam which did not change spontaneous firing rates markedly enhanced GABA-mediated inhibitions in rat cerebellum in situ and in tissue cultures of rat hypothalamus. The effects of diazepam were readily reversible, and could be antagonized by picrotoxin; no effect on glycine or norepinephrine-induced inhibition was seen. It is concluded that actions of diazepam are mediated, at least in part, by a specific increase in GABA-mediated inhibition in the central nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00495542
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