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  • Articles: DFG German National Licenses  (2)
  • Electron Microscopy  (1)
  • Tetrahydropapaverine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    An analysis of the ultrastructural findings in infantile neuroaxonal dystrophy (Seitelberger's disease) (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 201-213 
    Details
    ISSN: 1432-0533
    Keywords: Infantile Neuroaxonal Dystrophy ; Spheroids ; Perikaryon ; Electron Microscopy ; Membranous Profiles ; Dense Bodies ; Protein Syntheses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic findings of a cortical biopsy from a four-year-old child suffering from muscular weakness and psychomotor retardation are presented. Morphological evidence obtained in this study suggests a unique pathogenetic mechanism underlying INAD. The spheroids appear to be caused by an accumulation of a macromolecular substance synthesized in the neuron and transported to the nerve endings. The abnormal substance initially takes the form of an amorphous material, it eventually aggregates into highly characteristic angulated membranous profiles. The selective involvement of the nerve endings, synapses and motor end plates in this disease suggests a derangement of the metabolic pathway in the synthesis or packaging of the neurotransmitters or their receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687630
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain (1990)
    Springer
    Neurochemical research 15 (1990), S. 705-710 
    Details
    ISSN: 1573-6903
    Keywords: Tetrahydropapaverine ; tetrahydroisoquinoline ; tetrahydropapaveroline ; salsolinol ; NADH-ubiquinone oxidoreductase (Complex I) ; ATP ; mitochondrial respiration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the mitochondrial respiration by 1-methyl-4-phenylpyridinium ion (MPP+), we studied the effects of TIQ-like alkaloids including dopaminederived ones on the mitochondrial respiration using mouse brains. TIQ, tetrahydropapaveroline (THP), and tetrahydropapaverine (THPV) produced significant inhibition of the state 3 and 4 respiration and respiratory control ratio supported by glutamate + malate, the activity of Complex 1 and the ATP synthesis. Among those compounds, THPV was most potent. Toxic properties of these compounds on mitochondria were quite similar to that of MPP+. Our results support the hypothesis that (a) MPTP- or MPP+-like substance(s) may be responsible for the nigral degeneration in Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00973651
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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