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  • Articles: DFG German National Licenses  (2)
  • Epidemiology  (1)
  • Migraine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 7 (1991), S. 358-364 
    ISSN: 1573-7284
    Keywords: Infant death ; Congenital malformations ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The spatial and temporal distribution of infant death rates attributed to the single cause of congenital malformation (DCM) in Italy was studied for the period 1958–1981. Variation of DCM rates in this period was investigated for the whole country, for the three main geographical areas of the North, Center, and South, and for each of the 18 Italian regions (there are 20 administrative regions, but in this study Abruzzo were pooled with Molise and the Aosta Valley with neighbouring Piedmont). It was found that DCM decreases significantly with time. The decrease is considerable in the North and the Center of the country, whereas in the South temporal variation is minimal. There is a marked decrease of the variance of the DCM rates between regions with later years, possibly indicating a tendency to equalization of environmental effects in a large part of the peninsula.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Keywords: Migraine ; Lod score ; Sib-pair analysis ; Serotonin ; Calcium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario È stata condotta un'analisi di linkage ed associazione su 14 famiglie italiane con ricorrenza di emicrania. Abbiamo analizzato cinque regioni cromosomiche attorno ai geni candidati 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) e FHM (19p13), usando 29 marcatori polimorfici del DNA. Tutti i valori dei lod-score a due punti erano negatitivi, i x2 della sib-pair analysis non erano significativi, escludendo così la presenza di geni per l'emicrania nella popolazione in esame nelle regioni analizzate.
    Notes: Abstract A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3–34.3), 5HT1B (6q13), 5HT2A (13q14–21), 5HT transporter (17q11.2–12), CACNLB1 (17q11.2–22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the x2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.
    Type of Medium: Electronic Resource
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