ISSN:
1432-1335
Keywords:
N-Butyl-N-(4-hydroxybutyl)nitrosamine
;
Dose-response study
;
Urinary bladder tumor
;
F344 rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The highest dose induced urinary bladder cancer in all rats treated by week 91, decreasing yields being associated with lower dose levels: an incidence of 76.7% was observed with 10 ppm, followed by 20.0% with 5 ppm. The lowest dose (1 ppm) only induced two cases of papilloma (6.9%).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00390992
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