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  • Articles: DFG German National Licenses  (2)
  • Glycine max  (1)
  • Key words TCR-CD3  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Alteration of signal-transducing molecules in tumor-infiltrating lymphocytes and peripheral blood T lymphocytes from human colorectal carcinoma patients (1998)
    Springer
    Cancer immunology immunotherapy 45 (1998), S. 299-305 
    Details
    ISSN: 1432-0851
    Keywords: Key words TCR-CD3 ; TIL ; Colorectal cancer ; Protein tyrosine kinase (PTK) ; Immune suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Tumor development or growth is accompanied by impaired immune responses, such as a poor proliferative response or down-regulated cytolytic T lymphocyte activity. Although recent reports have suggested that modification of the signal-transducing molecule is responsible for impaired immune responses in tumor-bearing hosts, the causes of defective immune function are not yet completely understood. Furthermore, the clinical significance of the findings is not yet clear. In this study, we investigated the alteration of several signal-transducing molecules in peripheral blood T lymphocytes (T-PBL) as well as in tumor-infiltrating lymphocytes (TIL) from human colorectal carcinoma patients and their relationship with the impaired host immune responses. A greater reduction in CD3ζ chain level was observed in TIL than in T-PBL from tumor-bearing hosts. CD3ζ chain reduction in T-PBL correlated with the clinicopathological stage of a tumor, especially with the status of lymph node metastasis. The levels of p56 lck and p59 fyn protein tyrosine kinase in T-PBL were also compared between tumor-bearing hosts and normal healthy volunteers. In T-PBL from tumor-bearing hosts, expression of protein tyrosine kinase p59 fyn was significantly lower than that of p56 lck . However, the level of CD3ζ chain expression did not correlate with T lymphocyte functions such as T lymphocyte proliferative response or allogeneic target cell lysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050446
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Incompletely dominant single resistance gene for peanut stripe virus in soybean line AGS 129 (1989)
    Springer
    Euphytica 40 (1989), S. 193-196 
    Details
    ISSN: 1573-5060
    Keywords: Glycine max ; soybean ; genetics ; peanut stripe virus ; resistance ; incomplete dominance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Inheritance of resistance to a soybean isolate of peanut stripe virus (PStV-strain PN) was studied in three soybean varieties, AGS 129, Ankur, and PI 230971. Genetic analysis was based on necrotic, mosaic and symptomless reactions in inoculated soybeans. A single incompletely dominant gene in AGS 129 was found to confer the resistance to PStV and was tentatively designated as Pst. The homozygous parent AGS 129, possessing the genotype Pst Pst, was immune while Ankur and PI 230971, with a genotype of pst pst, were susceptible showing mosaic symptoms. The heterozygous genotype Pst pst resulting from the cross of either Ankur or PI 230971 with AGS 129 reacted with necrosis, distinctly different from either of the homozygous genotypes. This genotypic effect was confirmed through the phenotypic segregation in BC, F2, and F3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00024511
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    Paper (German National Licenses)
    Fulltext
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