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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of oncology 10 (1999), S. 593-595 
    ISSN: 1569-8041
    Keywords: Hodgkin's disease ; relapse ; salvage chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Refractory or relapsing Hodgkin's disease is associated with a poor prognosis. There is no widely accepted salvage chemotherapy regimen for these patients. However, the addition of high-dose chemotherapy followed by autologous hematopoietic transplantation (AHT) has proven of benefit to them. A prospective clinical trial was carried out to evaluate the efficacy and toxicity of ESHAP (etoposide, methylprednisolone, high-dose cytarabine, and cisplatin). Patients and methods: Twenty-two patients with refractory (5) or relapsing Hodgkin's disease (17) were entered and scheduled to receive three courses of ESHAP. Patients suitable for AHT were then given high-dose chemotherapy with CBV (cyclophosphamide, carmustine, and etoposide) plus AHT, whereas responding, non-AHT-suitable patients completed six ESHAP courses. Results: Nine patients achieved complete responses and seven partial responses (overall response rate 73%) with ESHAP. Grade 3–4 myelotoxicity was seen in 13 patients (59%). Nine patients received CBV plus AHT. At a median follow-up time of 50 months (range 6–96), seven patients (32%) are alive and disease-free. Three patients died of toxic effects of ESHAP (1) or CBV (2). Actuarial overall survival and disease-free survival were 35% and 27% at three years. Conclusions: ESHAP is an active regimen for relapsing Hodgkin's disease, with myelosuppression as its dose-limiting toxicity. An increased risk of treatment-related mortality when it is combined with high-dose chemotherapy can not be ruled out.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 43 (1998), S. 565-583 
    ISSN: 0029-5981
    Keywords: incompressibility ; tetrahedral ; linear ; elements ; explicit dynamic computation ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Explicit dynamic codes which are used currently for the study of plastic deformations in impact, or with some modification for metal forming, suffer two serious limitations.First, only quadrilateral or hexahedral linear elements can be used thus limiting the possibilities of adaptive refinement and adaptive meshing.Second, even with the use of such elements, special devices such as reduced integration must be introduced to avoid locking and reduce costs. These necessitate complex hour glass control, mending-type procedures.The main difficulties are those due to the need of treatment of (almost) incompressible deformation modes. Recently, similar difficulties have been overcome in the context of fluid dynamics soil dynamics and we show here how the processes introduced there can be adopted effectively to the present problem, thus allowing an almost unrestricted choice of element interpolations. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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