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  • Articles: DFG German National Licenses  (4)
  • Interferon-gamma  (2)
  • Japanese  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Aseptic meningitis in children: Correlation between fever and interferon-gamma level (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 722-725 
    Details
    ISSN: 1432-1076
    Keywords: Aseptic meningitis ; Fever ; Cytokine ; Interferon-gamma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the correlation between interleukin-1 beta (IL-1β), tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in cerebrospinal fluid (CSF) and clinical/laboratory findings in children with aseptic meningitis. In 19/27 patients (70%), the CSF IFN level was high at initial diagnosis, and reduced to a low or undetectable level during the convalescent phase (5–14 days later) of the disease. There were no differences in IL-1β and TNF-α levels between the acute and convalescent phase of the patients. The serum IFN-γ levels in the patients, which were simultaneously examined were undetectable in the acute phase. When we compared the clinical/laboratory findings between the 29 patients with detectable CSF IFN-γ level and the 21 patients with an undetectable CSF IFN-γ level in the acute phase, the former demonstrated higher body temperature (P〈0.01), and higher cell number and protein level in the CSF (P〈0.05) than the latter. On the other hand, there were no significant differences in the duration of meningeal signs, the titre of C-reactive protein, and the peripheral leucocyte count between the two groups. By the Spearman's rank sum test, the CSF IFN-γ levels correlated more definitively with the severity of febrile episode (maximal body temperature, duration of fever and body temperature at the first lumbar tap), and the cell number and protein level in the CSF. These results suggest that IFN-γ produced in the inflamed intrathecal space may be associated with the pathogenesis of aseptic meningitis, especially the production of fever.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958764
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The inflammatory cytokines in measles: Correlation between serum interferon-γ levels and lymphocyte subpopulations (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 492-496 
    Details
    ISSN: 1432-1076
    Keywords: Measles ; Interferon-gamma ; Inflammatory cytokine ; T-cell subsets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interleukin-1 (IL-1β), tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) were measured in serum from children with measles using an immunoradiometric assay. The IFN-γ level was increased in 52 out of 54 patients in the acute phase of measles (〈7 days of illness), and then declined to an undetectable level in the convalescent phase. Neither IL-1 nor TNF could be detected during the course of the illness. The mean serum IFN-γ level was at its peak on day 4 and could be detected over a 7-day period after the onset of fever, coinciding with the febrile period (6.9±1.5 days). In the acute phase, the phytohaemagglutinin responses, absolute number of platelets, total lymphocyte counts, CD3+, CD4+, CD8+ cell counts and the CD4/8 ratio were depressed, while stab cell number and lactate dehydrogenase levels were higher than those in the convalescent phase. Using Spearman rank sum test, the IFN-γ level was correlated negatively with the peripheral lymphocyte (P〈0.01), CD3+ (P〈0.05), CD4+ (P〈0.05) cell counts and the CD4/8 ratio (P〈0.05) and correlated positively with the stab cell count (P〈0.01) but not with any other parameter. When the acute phase findings were compared between 28 complicated and 40 uncomplicated patients, the former were younger (P〈0.01) and had higher maximum body temperature during the illness (P〈0.05) than the latter, there was no difference in their IFN-γ levels. These results show that endogenous IFN-γ appears in the circulation during the acute febrile phase of measles, but does not contribute directly to any complication of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957751
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The association of the insulin resistance syndrome with impaired glucose tolerance and NIDDM in the Japanese general population: the Hisayama study (1994)
    Springer
    Diabetologia 37 (1994), S. 897-904 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin resistance ; non-insulin-dependent diabetes mellitus ; impaired glucose tolerance ; population-based study ; epidemiology ; Japanese ; Hisayama study.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the risk factors for initiating glucose intolerance, the relevant factors were explored in a cross-sectional survey conducted in a sample population aged 40–79 years old selected from a Japanese community, Hisayama, Japan in 1988. A 75-g oral glucose tolerance test was used to classify 1,073 men (72.5 % of the entire population in the same age range) and 1,407 women (80.5 %) into normal, impaired glucose tolerance and diabetes mellitus groups. In all age and sex groups with normal glucose tolerance, the sum of fasting and 2-h post-load insulin values varied widely and demonstrated significant positive correlations with triglycerides, body mass index, waist-hip ratio, systolic and diastolic blood pressure, while it negatively correlated to HDL cholesterol (p 〈 0.05). Insulin resistance was presumed to develop in normal glucose tolerance subjects with hyperinsulinaemia. The sum of the insulin concentrations, triglycerides, body mass index, waist-hip ratio and blood pressure levels was significantly associated with impaired glucose tolerance in all age and sex groups after adjustment for age (p 〈 0.05) and was also related to diabetes in either all or some age and sex groups, respectively (p 〈 0.05). It was shown that glucose intolerance in the general population was associated with the factors related to insulin resistance. These cross-sectional data, therefore, support the hypothesis that insulin resistance is the primary defect in the development of glucose intolerance in the Japanese general population. However, a further prospective study is still needed in order to confirm this hypothesis. [Diabetologia (1994) 37: 897–904]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400945
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The association of the insulin resistance syndrome with impaired glucose tolerance and NIDDM in the Japanese general population: the Hisayama study (1994)
    Springer
    Diabetologia 37 (1994), S. 897-904 
    Details
    ISSN: 1432-0428
    Keywords: Insulin resistance ; non-insulin-dependent diabetes mellitus ; impaired glucose tolerance ; population-based study ; epidemiology ; Japanese ; Hisayama study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the risk factors for initiating glucose intolerance, the relevant factors were explored in a cross-sectional survey conducted in a sample population aged 40–79 years old selected from a Japanese community, Hisayama, Japan in 1988. A 75-g oral glucose tolerance test was used to classify 1,073 men (72.5% of the entire population in the same age range) and 1,407 women (80.5%) into normal, impaired glucose tolerance and diabetes mellitus groups. In all age and sex groups with normal glucose tolerance, the sum of fasting and 2-h post-load insulin values varied widely and demonstrated significant positive correlations with triglycerides, body mass index, waist-hip ratio, systolic and diastolic blood pressure, while it negatively correlated to HDL cholesterol (p〈0.05). Insulin resistance was presumed to develop in normal glucose tolerance subjects with hyperinsulinaemia. The sum of the insulin concentrations, triglycerides, body mass index, waist-hip ratio and blood pressure levels was significantly associated with impaired glucose tolerance in all age and sex groups after adjustment for age (p〈0.05) and was also related to diabetes in either all or some age and sex groups, respectively (p〈0.05). It was shown that glucose intolerance in the general population was associated with the factors related to insulin resistance. These cross-sectional data, therefore, support the hypothesis that insulin resistance is the primary defect in the development of glucose intolerance in the Japanese general population. However, a further prospective study is still needed in order to confirm this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400945
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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