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  • Articles: DFG German National Licenses  (3)
  • Ionosphere (plasma convection)  (1)
  • Key words: Gingival crevicular fluid — Periodontitis — Protease inhibitor — Collagenase — Bone resorption  (1)
  • Magnetospheric physics (magnetosphere-ionosphere interactions; polar wind-magnetosphere interactions)  (1)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    ISSN: 1420-908X
    Keywords: Key words: Gingival crevicular fluid — Periodontitis — Protease inhibitor — Collagenase — Bone resorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To determine whether an inhibitor of matrix metalloproteinases (MMPs), administered to human subjects in a dental school research clinic, can reduce bone-type collagen degradation fragments in oral inflammatory exudates containing excessive levels of collagenase.¶Materials and Subjects: Gingival crevicular fluid (GCF) was collected from 18 subjects with adult periodontitis whose clinical findings (gingival inflammation, pocket depth, and bone loss on radiographs) predicted excessive MMP activity in their periodontal pockets.¶Treatment: One month before the baseline appointment, plaque and calculus were removed from the teeth by supra- and subgingival scaling. After collection of GCF from 8–12 pocket sites per subject and recording of clinical indices, 12 of the 18 subjects were treated with doxycycline at a low dosage (20 mg b.i.d.) known via an extensive literature to suppress mammalian MMP activity by a non-antimicrobial mechanism. The remaining 6 subjects were followed without drug treatment.¶Methods: At the baseline, 1 and 2-month appointments, GCF samples were analyzed for ICTP (carboxyterminal peptide, a pyridinoline-containing fragment of Type I collagen) and osteocalcin by radioimmunoassay, as well as collagenolytic enzyme activity and MMP species (Western blot). Statistical analyses were determined by ANOVA.¶Results: GCF ICTP and functional collagenase activity (but not osteocalcin levels) were significantly reduced (p 〈 0.05) in the doxycycline-treated subjects at both 1 and 2 month evaluations; there was no such change in the non-treated subjects. Western blots revealed that neutrophil-type collagenase (MMP-8) was the predominant MMP; MMP-13, which has been associated with pathologic collagenolysis including bone resorption, was detected in human GCF for the first time and was more substantially reduced than MMP-8. ¶Conclusion: This is the first demonstration in human subjects of the simultaneous reduction of excessive MMP activity with concomitant reduction in levels of collagen degradation fragments. The findings are potentially applicable to a wide variety of human diseases characterized by excessive collagenase activity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0992-7689
    Keywords: Ionosphere (polar ionosphere) ; Magnetospheric physics (magnetosphere-ionosphere interactions; polar wind-magnetosphere interactions)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A long series of polar patches was observed by ionosondes and an all-sky imager during a disturbed period (Kp = 7- and IMF Bz 〈0). The ionosondes measured electron densities of up to 9 × 1011 m−3 in the patch center, an increase above the density minimum between patches by a factor of ≈4.5. Bands of F-region irregularities generated at the equatorward edge of the patches were tracked by HF radars. The backscatter bands were swept northward and eastward across the polar cap in a fan-like formation as the afternoon convection cell expanded due to the IMF By 〉 0. Near the north magnetic pole, an all-sky imager observed the 630-nm emission patches of a distinctly band-like shape drifting northeastward to eastward. The 630-nm emission patches were associated with the density patches and backscatter bands. The patches originated in, or near, the cusp footprint where they were formed by convection bursts (flow channel events, FCEs) structuring the solar EUV-produced photoionization and the particle-produced auroral/cusp ionization by segmenting it into elongated patches. Just equatorward of the cusp footprint Pc5 field line resonances (FLRs) were observed by magnetometers, riometers and VHF/HF radars. The AC electric field associated with the FLRs resulted in a poleward-progressing zonal flow pattern and backscatter bands. The VHF radar Doppler spectra indicated the presence of steep electron density gradients which, through the gradient drift instability, can lead to the generation of the ionospheric irregularities found in patches. The FLRs and FCEs were associated with poleward-progressing DPY currents (Hall currents modulated by the IMF By) and riometer absorption enhancements. The temporal and spatial characteristics of the VHF backscatter and associated riometer absorptions closely resembled those of poleward moving auroral forms (PMAFs). In the solar wind, IMP 8 observed large amplitude Alfvén waves that were correlated with Pc5 pulsations observed by the ground magnetometers, riometers and radars. It is concluded that the FLRs and FCEs that produced patches were driven by solar wind Alfvén waves coupling to the dayside magnetosphere. During a period of southward IMF the dawn-dusk electric field associated with the Alfvén waves modulated the subsolar magnetic reconnection into pulses that resulted in convection flow bursts mapping to the ionospheric footprint of the cusp.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0992-7689
    Keywords: Ionosphere (plasma convection) ; Magnetospheric physics (magnetopause, cusp, and boundary layers; magnetosphere-ionosphere interactions)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Three SuperDARN coherent HF radars are employed to investigate the excitation of convection in the dayside high-latitude ionosphere in response to transient reconnection occurring in the cusp region. This study demonstrates the existence of transient antisunward-propagating backscatter features at the expected location of the ionospheric footprint of the cusp region, which have a repetition rate near 10 min. These are interpreted as the ionospheric signature of flux transfer events. Moreover, transient sunward-propagating regions of backscatter are observed in the convection return flow regions of both the pre- and post-noon sectors. These patches are observed to propagate towards the noon sector from at least as far around the auroral zone as 07 MLT in the pre-noon sector and 17 MLT in the post-noon sector, travelling with a veloCity of approximately 1.5 to 2 km s−1. These return flow patches have a repetition rate similar to that of the transient features observed at local noon. While providing supporting evidence for the impulsive nature of convection flow, the observation of sunward-propagating features in the return flow region is not consistent with current conceptual models of the excitation of convection.
    Type of Medium: Electronic Resource
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