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  • Articles: DFG German National Licenses  (2)
  • Ischemia  (1)
  • Theophylline  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    The effects of theophylline and papaverine in enhancing skin expansion in guinea pigs (1988)
    Springer
    European journal of plastic surgery 11 (1988), S. 60-64 
    Details
    ISSN: 1435-0130
    Keywords: Tissue expansion ; Myofibroblasts ; Theophylline ; Papaverine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was designed to assess the effectiveness of Papaverine and Theophylline for the enhancement of tissue expansion. Twentyfour guinea pigs were evenly assigned to three groups. One group served as control, the other two were experimental. In one group, Papaverine was used for enhancement of tissue expansion, in the other, Theophylline. It was assumed that by using anticontractile agents, formation of the fibrous capsule around the expander could be inhibited, thus enhancing tissue expansion. The study revealed that the rate of expansion was significantly increased with the use of either agent, but it appears that there is no significant difference in the effectiveness of the two agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299211
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The effects of calcium channel blockers on random skin flap survival in the pig model (1991)
    Springer
    European journal of plastic surgery 14 (1991), S. 3-6 
    Details
    ISSN: 1435-0130
    Keywords: Skin flap ; Calcium channel blockers ; Ischemia ; Animal models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to evaluate the influence of two calcium channel blockers, verapamil and nifedipine, on skin flap survival. These agents were selected because they inhibit the passage of calcium through calcium selective channels in the plasma membrane, thereby blocking calcium mediated electromechanical coupling in contractile tissue and resulting in peripheral arterial vasodilation. Three groups of pigs were used in this study. All skin flaps in this study were 3 cm wide and 12 cm long. The first group (10 flaps) served as controls with no pharmacologic manipulations. Pigs in group II (15 flaps) received verapamil (80 mg orally, three times a day) for 7 days postoperatively. Pigs in group III (15 flaps) received nifedipine (10 mg orally, three times a day) for 7 days postoperatively. Statistical analysis of the results demonstrated that both verapamil and nifedipine resulted in significant enhancement of skin flap survival. The increased survival of the skin flaps produced by nifedipine as compared to verapamil was statistically significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585579
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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