ISSN:
1435-1803
Keywords:
Key words Endothelin – cardiovascular system – receptor – pathophysiology – physiology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1 appears to be the most relevant in humans. They act in a paracrine manner on ETA and ETB receptors. ET-1 plays an important role in the cardiovascular system. In addition, it modulates vasomotion and growth processes, and it participates in thrombogenesis and neutrophil adhesion. This review summarizes some of the current literature pertaining to the physiological and pathophysiological significance of ET-1, focusing the assets and drawbacks of elevated ET-1 levels. In this regard, modulation of the endothelin system by either receptor blockade or by inhibition of endothelin converting enzyme is expected to provide novel therapeutic drug strategies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003950070048
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