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  • Articles: DFG German National Licenses  (2)
  • Key words Medulloblastoma  (1)
  • metastatic disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Child's nervous system 14 (1998), S. 2-5 
    ISSN: 1433-0350
    Keywords: Key words Medulloblastoma ; Chemotherapy ; Modern treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chemotherapy has an important role in the modern treatment of children with medulloblastoma (MB). In patients at high risk, intense chemotherapy should improve the survival rate. In low-risk patients chemotherapy should allow the dose of craniospinal irradiation to be reduced, which in turn should improve the quality of life. In infants under 3 years of age radiotherapy should be delayed, or even replaced by postoperative chemotherapy. Chemotherapy is also necessary to prevent or treat systemic dissemination. The optimal timing of chemotherapy is a focus of contemporary research.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7373
    Keywords: childhood brain tumor ; metastatic disease ; diagnosis en treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastatic disease is a major problem in the management of the most frequent childhood brain tumors, in ependymoma and primitive neuroectodermal tumors (PNET). Today, contrast enhanced craniospinal MRI and careful analysis of craniospinal fluid are a prerequisite for correct staging of both tumors and imply therapeutic consequences. So far metastatic spread of medulloblastoma and some ependymomas is prevented by conventional chemotherapy and radiotherapy. However, some forms of diffuse metastatic dissemination in medulloblastoma are resistant to conventional therapeutic regimens and require new experimental strategies.
    Type of Medium: Electronic Resource
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